Peptide T and related peptides in the treatment of inflammation,

Details Peptide T and related peptides in the treatment of inflammation, Peptide T and related peptides in the treatment of inflammation,

1998-05-21

2000-01-04

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 16, 514 17, 514 18, 530328, 530329, 530330, A61K 3800, C07K 500, C07K 700

Patent

active

060110147

ABSTRACT:
A method of treating or preventing multiple sclerosis in a patients in need of such treatment by administering an effect amount of the peptide: I-A-B-C-D-E-F-G-H-II (General Formula) wherein A is Ala, Gly, Val, Ser, Thr or absent, B is Ala, Gly, Val, Ser, Thr or absent, C is Ser, Thr or absent, D is Ser, Thr, Asn, Glu, Arg, IIe, Leu or absent, E is Ser, Thr, Asp or absent, F is Thr, Ser, Asn, Glu, Lys, Trp or absent, G is tyr or absent; H is Thr, Arg, Gly, Met, Met(O), Gys, Thr, Gly or absent, I is Cys or absent, II is Cys, an amide group, substituted amide group, an ester group or absent.

REFERENCES:
patent: 5686417 (1997-11-01), McFadden et al.
patent: 5756449 (1998-05-01), Andersen et al.
Cotelle, et al Biochem&BiophysResComm. vol. 171, No. 2. pp. 596-602, Sep. 14, 1990.
Urge, et al; Biochem&BiophysResComm. vol. 184, No. 2, pp. 1125-1132. Apr. 30, 1992.

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