Peptide synthesis with sulfonyl protecting groups

Details Peptide synthesis with sulfonyl protecting groups Peptide synthesis with sulfonyl protecting groups

1997-11-21

1999-08-24

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530337, 562430, 562556, C07K 104, C07K 106

Patent

active

059426012

ABSTRACT:
Methods and compositions are provided for synthesizing peptides with sulfonyl protecting groups. In the subject methods, an sulfonyl group .alpha.-amino protected amino acid is contacted with a second amino acid monomeric unit under coupling conditions so that the protected amino acid and second amino acid monomeric unit are joined by a peptide bond. The contacting step may be repeated one more additional times to obtain a peptide of desired length. Also provided are methods of site specific modification using the subject sulfonyl protecting groups. The subject methods find particular use in methods of solid phase peptide synthesis.

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