Peptide synthesis method and solid support for use in the method

Details Peptide synthesis method and solid support for use in the method Peptide synthesis method and solid support for use in the method

1992-12-14

1994-12-13

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525 5411, 530333, 530334, C07C10352, C07D 5152

Patent

active

053730534

ABSTRACT:
A method for the solid-phase synthesis of peptides or proteins in high yield and high purity uses a solid support consisting of a functionalized polystyrene-grafted polymer substrate, the grafted polystyrene chains being substantially non-cross-linked and having a chain molecular weight, not including optional non-reactive substituents, of at least 200,000, preferably in the range of 600,000-1,200,000. Particularly suitable polymer substrates are substrates of a polyolefin such as polyethylene. The method is particularly well-suited to the compartmentalized synthesis of a multitude of peptides or proteins in a parallel and substantially simultaneous fashion.
Preferred embodiments of a solid support for performing the synthesis are prepared from thin polyethylene sheet or film which has been grafted with polystyrene chains in a radical-initiated process in which the polyethylene sheet or film is immersed in a solution of optionally substituted styrene monomer in an alcohol such as methanol, the volume percentage of styrene in the solution preferably being about 30% v/v, and subjected to gamma irradiation.

REFERENCES:
patent: 3795664 (1974-03-01), Tregear et al.

Affiliated with

Also associated with

Rating

Peptide synthesis method and solid support for use in the method does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptide synthesis method and solid support for use in the method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide synthesis method and solid support for use in the method will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1193961