Peptide substrates recognizable by a botulinum toxin A,...

Details Peptide substrates recognizable by a botulinum toxin A,... Peptide substrates recognizable by a botulinum toxin A,...

2011-01-25

2011-01-25

Cordero Garcia, Marcela M (Department: 1654)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

C514S013800, C514S014800, C514S015800, C514S016700, C530S326000, C530S328000, C530S329000, C530S330000

Reexamination Certificate

active

07875436

ABSTRACT:
A peptide substrate selectively recognisable by a botulinum toxin A, BoNT/A containing a Nop-(Z)-Pya fragment in the peptide structure thereof, wherein Z is an aminoacid chain, preferably RA and the fragment is cleaved by the toxin.

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Soleilhac et al: “A sensitive and rapid fluorescence-based assay for determination of tetanus toxin peptidase activity” Analytical Biochemistry, Academic Press, San Diego, CA, US, vol. 241, 1996, pp. 120-127, XP002160418 ISSN: 0003-2697 the whole document.
Luciani N et al: “Highly Sensitive and Selective Fluorescence Assays for Rapid Screening of Endothelin-Converting Enzyme Inhibitors” Biochemical Journal, The Biochemical Society, London, GB, vol. 356, No. 3, Jun. 15, 2001, pp. 813-819, XP001025608 ISSN: 0264-6021 the whole document.

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