Peptide substrates for detecting virus-specified protease activi

Details Peptide substrates for detecting virus-specified protease activi Peptide substrates for detecting virus-specified protease activi

1987-04-13

1990-08-28

Spiegel, Jack

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 23, 435 24, 530300, 530330, 530345, 530802, 530807, 530826, C12Q 170, C12Q 138, C12Q 136

Patent

active

049524933

ABSTRACT:
A method for preparing selected peptide substrates for detecting the activity of virus-specified proteases is provided. Specific tetrapeptide substrates are disclosed which are conjugates of protease-cleavable indicator groups and peptide sequences resembling picornavirus protease cleavage recognition sites.

REFERENCES:
Korant, "Inhibition of Viral Protein Cleavage" in Antiviral Chemotherapy, Gauri, ed., (Academic Press, New York, 1981).
Korant, "Regulation of Animal Virus Replication by Protein Cleavage", in Proteases and Biological Control, (Cold Spring Harbor Laboratory, 1975).
Lozitskii et al., Usp. Sovrem. Biol. 93: 352-362 (1982).
Korant et al., Proc. Natl. Acad. Sci. USA 76: 2992 (1979).
Korant et al., Ann. N.Y. Acad. Sci. 343: 304 (1980).
Korant et al., "Picornaviruses and Togaviruses: Targets for Design of Antivirals", in Targets for the Design of Antiviral Agents, DeClercg et al., ed. (Plenum, New York, 1984).

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