Peptide substrate identified by type BoNT/B botulinus toxin...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S324000, C530S326000, C530S333000, C435S004000, C435S007720

Reexamination Certificate

active

10296396

ABSTRACT:
A peptide substrate is identified by type BoNT/B botulinus toxin, characterized in that it incorporates in its structure a fragment of formula PYA-(Z)-pNF, wherein Z represents one or several amino acids, said fragment being cleavable by said toxin.

REFERENCES:
patent: 4698327 (1987-10-01), Nagarajan et al.
patent: 5962637 (1999-10-01), Shone et al.
patent: 2003/0143651 (2003-07-01), Steward et al.
patent: WO 95 33850 (1995-12-01), None
C. Anne, et al. Anal. Biochem. (2001) 291, 253-261, published online Mar. 9, 2001.
J. Rudinger. In: Peptide Hormones, JA Parsons, Ed. (1976) 1-7.
W.S. Messer, “Vasopressin and Oxytocin”, web document updated Apr. 3, 2000; <http://www.neurosci.pharm.utoledo.edu/MBC3320/vasopressin.htm>; 5 pages.
S. Rudikoff, et al. Proc. Natl. Acad. Sci. USA (1982) 79, pp. 1979-1983.
S.-Y. Hua, and M.P. Charlton. Nature Neurosci. (1999) 2(12), pp. 1078-1083.
D. Voet and J.G. Voet. Biochemistry, 2nd Edition.(1995), pp. 235-241.
D.E. Smilek, et al. Proc. Natl. Acad. Sci. USA (1991) 88, pp. 9633-9637.
Soleilhac et al.: “A sensitive and rapid fluorescence-based assay for determination of tetanus toxin peptidase activity,” Analytical Biochemistry, vol. 241, 1996, pp. 120-127.
Fitzgerald et al.: “A continuous fluorometric assay for the feline immunodeficiency virus protease,” Analytical Biochemistry, vol. 54, Dec. 15, 1997, pp. 226-230.
Peranteau et al.: “Increase in fluorescence upon the hydrolysis of tyrosine peptides: Application to proteinase assays,” Analytical Biochemistry, vol. 227, No. 1, 1995, pp. 242-245.
Martin et al.: “Metallopeptidase inhibitors of tetanus toxin: A combinatorial approach,” Journal of Medical Chemistry, vol. 42, 1999, pp. 515-525.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Peptide substrate identified by type BoNT/B botulinus toxin... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptide substrate identified by type BoNT/B botulinus toxin..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide substrate identified by type BoNT/B botulinus toxin... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3741021

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.