Peptide substance revealing an immunogeroprotective effect,...

Details Peptide substance revealing an immunogeroprotective effect,... Peptide substance revealing an immunogeroprotective effect,...

2007-03-02

2011-11-15

Russel, Jeffrey E (Department: 1654)

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

C514S021900, C530S331000

Reexamination Certificate

active

08057810

ABSTRACT:
Disclosed is a pharmaceutical composition for the prevention and correction of age-related disorders of cellular and humoral immunity and having an immunogeroprotective effect. The pharmaceutical composition includes a peptide glutamyl-aspartyl-proline with general formula H-Glu-Asp-Pro-OH sequence 1 [SEQ ID NO:1]. The pharmaceutical composition can be in the form suitable for parenteral administration. Also disclosed is a method of prevention and/or correction of age-related disorders of cellular and humoral immunity by stimulating the processes of lymphocytes proliferation and differentiation, such method consisting in the administration to a patient of a pharmaceutical composition containing an effective amount of peptide glutamyl-aspartyl-proline with general formula: H-Glu-Asp-Pro-OH sequence 1 [SEQ ID NO:1] in the dose of 0.01-100 μg/kg of body weight as an active base at least once a day during a period necessary for attaining a therapeutic effect.

REFERENCES:
patent: 6727227 (2004-04-01), Khavinson
patent: WO 01/47950 (2001-06-01), None
patent: WO 2005/056580 (2005-06-01), None
patent: WO 2006/001728 (2006-01-01), None
patent: WO 2007/136294 (2007-11-01), None
patent: WO 2007/136295 (2007-11-01), None
patent: WO 2007/139431 (2007-12-01), None
Ruiz-Alcaraz et al. Gonadins, a novel family of glutamyl-tripeptide amides . . . Regulatory Peptides. 2005, vol. 129, pp. 93-101.
Mileusnic, R. et al., “The Peptide Sequence Arg-Glu-Arg, Present in the Amyloid Precursor Protein, Protects Against Memory Loss Caused by Abeta and Acts as a Cognitive Enhancer” European Journal of Neuroscience, Apr. 2004, pp. 1933-1938, vol. 19, No. 7, Oxford University Press, Great Britain.
Khavinson, V Kh. et al., “Mechanisms Underlaying Geroprotective Effects of Peptides” Bulletin of Experimental Biology and Medicine, Jan. 2002, pp. 1-5, vol. 133, No. 1, Consultants Bureau, New York, NY.
Korkushko O. V. et al., “Geroprotective Effect of Epithalamine (Pineal Gland Peptide Preparation) in Elderly Subjects with Accelerated Aging” Bulletin of Experimental Biology and Medicine, Sep. 1, 2006, pp. 356-359, vol. 142, No. 3, Kluwer Academic Publishers, NE.
Wang Chao et al., “The Synthesis and Immunosuppressive Activities of Steroid-urotoxin Linkers” Bioorganic & Medicinal Chemistry, Aug. 15, 2004, pp. 4403-4421, vol. 12, No. 16.
Barabanova, S.V. et al., “[Parallel Analysis of C-Fos Protein and Interleukin-2 Expression in Hypothalmic Cells Under Different Influence]” Feb. 2007, pp. 150-160, vol. 92, No. 2, Rossi §SKII Fiziologicheski § Zhurnal Imeni I.M. Sechenova, Rossi §Skaia Akademiia Nauk.
Sibarov, D.A. et al., “Epitalon Influences Pineal Secretion in Stress-Exposed Rats in the Daytime” Neuroendocrinology Letters, 2002, pp. 452-454, vol. 23, No. 5-6, Sweden.
Abiko, Takashi, et al., “Characterization of an Acidic Tripeptide in Neutotoxic Dialysate,”Chemical&Pharmaceutical Bulletin,vol. 28, No. 5, May 1980, pp. 1629-1633.

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