Peptide substance revealing a stress protective effect,...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C530S300000, C530S331000

Reexamination Certificate

active

08071556

ABSTRACT:
Disclosed is a peptide glutamyl-aspartyl-glycine with general formula H-Glu-Asp-Gly-OH sequence1[SEQ ID NO:1], having a stress protective effect. Also disclosed is a pharmaceutical composition comprising the peptide and a pharmaceutically acceptable carrier. Also disclosed is a method of preventing or treating functional or stress induced disorders in a patient wherein the method involves administering an effective amount of the peptide to the patient.

REFERENCES:
patent: 6727227 (2004-04-01), Khavinson et al.
patent: WO 01/47950 (2001-07-01), None
patent: WO 2005/056580 (2005-06-01), None
patent: WO 2006/001728 (2006-01-01), None
patent: WO 2007/136294 (2007-11-01), None
patent: WO 2007/139431 (2007-12-01), None
patent: WO 2007/139435 (2007-12-01), None
Abiko T, Onodera I, Sekino H, “Characterization of an Acidic Tripeptide in Neurotoxic Dialysate,” Chem. Pharm. Bull., 1980, 28(5): 1629-1633.
Mileusnic, R. et al., “The Peptide Sequence Arg-Glu-Arg, Present in the Amyloid Precursor Protein, Protects Against Memory Loss Caused by Abeta and Acts as a Cognitive Enhancer” European Journal of Neuroscience, Apr. 2004, pp. 1933-1938, vol. 19, No. 7, Oxford University Press, Great Britain.
Khavinson, V Kh. et al., “Mechanisms Underlaying Geroprotective Effects of Peptides” Bulletin of Experimental Biology and Medicine, Jan. 2002, pp. 1-5, vol. 133, No. 1, Consultants Bureau, New York, NY.
Korkushko O. V. et al., “Geroprotective Effect of Epithalamine (Pineal Gland Peptide Preparation) in Elderly Subjects with Accelerated Aging” Bulletin of Experimental Biology and Medicine, Sep. 1, 2006, pp. 356-359, vol. 142, No. 3, Kluwer Academic Publishers, NE.
Wang Chao et al., “The Synthesis and Immunosuppressive Activities of Steroid-urotoxin Linkers” Bioorganic & Medicinal Chemistry, Aug. 15, 2004, pp. 4403-4421, vol. 12, No. 16.
Barabanova, S.V. et al., “[Parallel Analysis of C-Fos Protein and Interleukin-2 Expression in Hypothalmic Cells Under Different Influence]” Feb. 2007, pp. 150-160, vol. 92, No. 2, Rossi §SKII Fiziologicheski § Zhurnal Imeni I.M. Sechenova, Rossi §Skaia Akademiia Nauk, English abstract only.
Sibarov, D.A. et al., “Epitalon Influences Pineal Secretion in Stress-Exposed Rats in the Daytime” Neuroendocrinology Letters, 2002, pp. 452-454, vol. 23, No. 5-6, Sweden.
Ruiz-Alcaraz, Antonio J., et al., “Gonadins, a novel family of glutamyl-tripeptide amides present in the testis with activity in the hypophyseal-gonadal axis,”Regulatory Peptides,vol. 129, 2005, pp. 93-101.

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