Peptide sequences and antipeptide antisera for detecting human c

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 11 to 14 amino acid residues in defined sequence

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530300, 530812, 435177, 435 43, A61K 3702, C07K 500, C07K 700, C07K 1500

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active

054592399

ABSTRACT:
This invention discloses novel immunogenic peptide sequences, derived from the human cyclooxygenase-1 and cyclooxygenase-2 cDNAs which elicit specific non cross-reactive antibody responses. Assays are also disclosed for selectively and independently detecting cyclooxygenase-1 or cyclooxygenase-2 proteins present in a given biological sample.

REFERENCES:
Hla et al. 1992. Human cyclooxygenase-2 cDNA. PNAS. 89:7384-7388.
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Devereux, J. et al. Nucleic Acids Res. 12:387-395 (1984).
Elroy-Stein, O. et al. Proc. Natl. Acad. Sci. 86:6126-6130 (1989).
Funk, C. D. et al. FASEB J. 5:2304-2312 (1991).
Harlow, E. et al. A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York (1988), pp. 72-87, 283-318, 553-612.
Laemmli, U.K. Nature 227:680-685 (1970).
Moss, B. et al. Nature 348:91-92 (1990).
Mumby, S. et al. J. Biol. Chem. 263:2020-2026 (1988).
Towbin, H. et al. Proc. Natl. Acad. Sci., USA 76:4350-4354 (1979).

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