Peptide scaffolds for transfer of molecules into eukaryotic...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

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C530S323000, C530S324000, C530S350000, C530S358000

Reexamination Certificate

active

06927278

ABSTRACT:
Compositions and methods of using compositions with a nuclear targeting peptide containing a nonclassical nuclear localization signal to deliver selected molecules to the nucleus of eukaryotic cells are provided. The compositions are useful for gene transfer.

REFERENCES:
patent: 5260189 (1993-11-01), Formoso et al.
patent: 5354844 (1994-10-01), Beug et al.
patent: 5661025 (1997-08-01), Szoka et al.
patent: 5922859 (1999-07-01), Birnstiel et al.
patent: WO 92/13570 (1992-08-01), None
patent: WO 96 41606 (1996-12-01), None
Rudinger (In Peptide Hormones J.A. Parsons, Ed. University Park Press, Baltimore, 1976, pp. 1,6, and 7.
Ngo et al (In The Protein Folding Problem and Tertiary Structure Prediction, K. Merz Jr. and S. Legrand, Eds. Birkhauser, Boston, 1994, pp. 433 and 492-495.
Jost et al (Nucl. Acids Res. (1997) 25(15): 3131-3134).
Gorlich et al (Journal of Cell Biology, (Jul. 14, 1997) 138 (1) 65-80).
Jakel et al (Embo Journal, (May 4, 1999) 18 (9) 2411-23).
Grondin et al (J. Biol. Chem. 271(26): 15458-15467, 1996).
Sachdev et al (Mol. Cell. Biol. 18(5): 2524-2534, 1998).
Fan et al (PNAS 95: 15293-15298, 1998).
Michael et al (Cell 82(3): 415-422, 1995).
Gallouzi et al (SCIENCE, (Nov. 30, 2001) 294 (5548) 1895-901).
Michael et al (EMBO J. 16(12): 3587-3598, 1997).
Jans et al., “Signals Mediating Nuclear Targeting and Their Regulation: Application in Drug Delivery”,Medicinal Research Reviews1998 18:4 189-223.
Chan et al., “Mutual exclusivity of DNA binding and nuclear localization signal recognition by the yeast transcription factor GAL4:implications for nonviral DNA delivery”Gene Therapy1998 5:1204-1212.
Shen W-C., “Nuclear import of DNA: the ultimate targeting in gene therapy”,Journal of Drug Targeting1997 5(1): 11-13.

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