Chemistry: molecular biology and microbiology – Vector – per se
Patent
1991-11-22
1994-11-22
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Vector, per se
4352402, 4351723, 435 691, 935 11, 935 22, 935 70, 935 27, 800 2, 800DIG1, C12N 1500, C12N 500
Patent
active
053668944
ABSTRACT:
A method of producing a substance comprising a peptide, involves incorporating a DNA sequence coding for the peptide into a gene of a mammal (such as a sheep) coding for a milk whey protein in such a way that the DNA sequence is expressed in the mammary gland of the adult female mammal. The substance may be an (optionally modified) protein such as a blood coagulation factor. The DNA sequence is preferably inserted into the first exon of a gene coding for a whey protein such as beta-lactoglobulin. The substance will generally be recovered from milk of the female mammal, but may (for example if it is an enzyme) be used in situ.
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Clark Anthony J.
Lathe Richard
Chambers Jasemine C.
Pharmaceutical Proteins Limited
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