Peptide process

Details Peptide process Peptide process

1995-05-26

1996-04-23

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530313, 530334, 530345, C07K 723, C07K 706

Patent

active

055104606

ABSTRACT:
A process for the solid phase synthesis of peptides containing an aza-amino acid, for example the decapeptide goserelin, which comprises:

REFERENCES:
patent: 4100274 (1978-07-01), Dutta et al.
Dutta et al. J.C.S. Perkin I (1975) 1712-1720.
Folkers et al. Z. Natur. B: Anorg. Chem. Org. Chem. 37B (8), 1075-1081 (1982).
Folkers et al.; "Synthesis and Bioassay of Antagonists of the Luteinizing Hormone Releasing Hormone Having The Azagly-10 Moiety; Zeitschrift fur Naturforschung" p. 1076, Col. 1-2 (Aug. 1982).
Dutta et al.; "Polypeptides, Part X111. Preparation of Alpha-Aza-Amino Acid (Carbazic Acid) Derivatives and Intermediates for the Preparation of Alpha-Aza-Peptides"; Journal of the Chemical Society; pp. 1712-1720 (1975).
Cotton et al.; "The Synthesis of D-Ser(But)-6,Azgly-10! LHRH (Zoladex-R*) By Solid-Phase Procedures Twelfth American Peptide Symposium", Mass. Inst. of Technology, Cambridge, Program and Abstracts, p. 412 (Jun. 1991).
Knolle et al., Solid phase synthesis of glycosylated LHRH antagonists with C-terminal azaglycine-amide, Peptides, pp. 414-415, 1990.

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