Peptide plasminogen activators

Details Peptide plasminogen activators Peptide plasminogen activators

1986-12-22

1996-03-26

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435226, 435 691, 424 9463, C12N 1500, C12N 964, A61K 3849

Patent

active

055018530

ABSTRACT:
Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, enhanced specific activity, reduced response to inhibition by plasminogen activator inhibitor, fibrin stimulation of plasminogenolytic activity and/or enhanced affinity to fibrin surfaces are provided by modifying one or more loci by deletions or substitutions. One or both of the N- or C-termini may be modified.

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Gordon A. Vehar et al., "Characterization Studies on Human Melanoma Cell Tissue Plasminogen Activator," Biotechnology, vol. 2, pp. 1051-1057 (1986).
Diane Pennica et al., "Cloning and Expression of Human Tissue-Type Plasminogen Activator cDNA in E. coli.", Nature, vol. 301, No. 5897, pp. 214-221.
Pohl, G. et al, Biochemistry, vol. 23, pp. 3701-3707, 1984.
Zoller, M. et al, Nucleic Acids Res., vol. 10, pp. 6487-6500, 1982.
Opdennaker, G. et al, EMBO Workshop on Plasminogen Activators, Amalpi, Italy, Oct. 14-18, 1985.

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