Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Insulin; related peptides
Patent
1998-03-12
2000-08-01
Davenport, Avis M.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Insulin; related peptides
530300, 530331, 530332, 530212, 514 6, 514 18, A61K 3828, A61K 3816, C07K 500, C07K 700
Patent
active
060968613
ABSTRACT:
A chemical complex comprising divalent metal ions, preferably Ca.sup.+2 ions, and peptide-peptoid trimers in a fixed ratio and having a centrosymmetric crystalline structure wherein three divalent metal ions at the interior of the complex are coordinated with the peptide carboxylate and urethane oxygen atoms. The globular complex has a hydrophobic outer surface and is useful as an ionophore.
REFERENCES:
patent: 5118665 (1992-06-01), Pickart
patent: 5120831 (1992-06-01), Pickart
patent: 5164367 (1992-11-01), Pickart
patent: 5470876 (1995-11-01), Procter
patent: 5538945 (1996-07-01), Pallenberg et al.
patent: 5550183 (1996-08-01), Pickart
Altura, B.M. (1996) Magnesium-neurohypophyseal hormone interactions in contraction of vascular smooth muscle. Am. J. Physiol. 228(5):1615-1620.
Ananthanarayanan, V.S., Orlicky, S. (1992) Interaction of substance P and its N- and C-terminal fragments with Ca.sup.2+ : implications for hormone action. Biopolymers 32:1765-1773.
Brimble, K.S., Ananthanarayanan, V.S. (1993) Calcium binding and translocation properties of glucagon and its fragments. Biochemistry 32(6):1632-1640.
Di Scala-Guenot, D., Strosser, M. (1992) Oxytocin receptors on cultured astroglial cells. Biochem. J. 284:499-505.
Epand, R.M. (1982) Cation-induced conformational change in glucagon. Mol. Pharmacol. 22:105-108.
Gerega, K., Kozlowski, H., Masiukiewicz, E., Pettit, L.D., Pybum, S., Rzeszotarska, B. (1988) Metal complexes of luteinizing hormone-releasing hormone (LHRH) potentionmetric and.
Goodman, G., Melacini, G., Feng, Y. (1996) Collagen-like triple helices incorporating peptoid residues. J. Am. Chem. Soc, 118:10928-10929.
Gopalakrishnan, V., McNeill, J.R., Sulakhe, P.V. Triggle, C.R. (1988) Hepatic vasopressin receptor: differential effects of divalent cations, guanine nucleotides, and N-ethylmaleimide on agonist and antagonist interactions with the V.sup.1 subtype receptor. Endocrinology 123(2):922-931.
Hill, C.P., Dauter, Z, Dodson, E.J., Dodson, G.G., Dunn, M.F. (1991) X-ray structure of an unusual Ca.sup.2+ site and the roles of Zn.sup.2+ and Ca.sup.2+ in the assembly, stability, and storage of the insulin hexamer. Biochemistry 30:917-924.
Kartha, G., Varughese, K.I., Aimoto, S. (1982) Conformation of cyclo(-L-Pro-gly-).sub.3 and its Ca.sup.2+ and Mg.sup.2+ complexes. Proc. Natl. Acad. Sci. USA 79:4519-4522.
Madison, V., Atreyi, M., Deber, C.M. Blout, E.R. (1974) Cyclic peptides. IX. conformations of a synthetic ion-binding cyclic peptide, cyclo-(Pro-Gly).sub.3, from circular dichroism and .sup.1 H and .sup.13 C nuclear magnetic resonance. J. Amer. Chem. Soc. 96:21 6725-6734.
Melancini, G., Feng, Y., Goodman, M. (1996) Collagen-based structures containing the peptoid residue N-Isobutylglycine (Nleu). 6. conformational analysis of gly-pro-nleu.
Moehle, K., Hofmann, H. (1996) Peptides and peptoids--a quantum chemical structure comparison. Biopolymers 38:781-790.
Pearlmutter, A.F., Soloff, M.S. (1979) Characterization of the metal ion requirement for oxtocin-receptor interaction in rat mammary gland membranes. J. Biol. Chem. 254(10):3899-3906.
Peggion, E., Mammi, S., Palumbo, M. (1984) Interaction of metal ions with gastrointestinal hormones: binding studies of Mg.sup.++ to biologically active analogs of little gastrin and minigastrin. Biopolymers 23:1225-1240.
Pliska, V., Kohlhauf Albertin, H. (1991) Effect of Mg.sup.2+ on the binding of oxytocin to sheep myometrial cells. Biochem. J. 277:97-101.
Seetharama Jois, D.S., Sridhar Prasad, G., Bednarek, M., Easwaran, K.R.K., Vijayan, M. (1993) Structure and conformation of the calcium complex of cyclo(ala-leu-pro-gly).sub.2 in two crystal forms. Int. J. Peptide Protein Res. 41:484-491.
Seetharama Jois, D.S., Easwaran, K.R.K., Bednarek, M., Boult, E.R. (1993) Conformational and ion binding properties of a cyclic octapeptide, cyclo(ala-leu-pro-gly).sub.2. In. J. Peptide.
Varughese, K.I., Aimoto, S., Kartha, G. (1986) Calcium binding cyclic hexapeptide. Int. J. Peptide Protein Res. 27:118-122.
Williams, P.F., Caterson, I.D., Cooney, G.J., Zilkens, R.R., Turtle, J.R. (1990) High affinity insulin binding and insulin receptor-effector coupling: modulation by Ca.sup.2+. Cell Calcium 11:547-556.
Jefferson et al., J. Am Chem Soc., vol. 119, No. 13, pp 3189-3190, 1997.
Goodman Murray
Jefferson Elizabeth
Davenport Avis M.
Kirkpatrick Anita M.
The Regents of the University of California
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