Peptide nucleic acids complexes of two peptide nucleic acid stra

Details Peptide nucleic acids complexes of two peptide nucleic acid stra Peptide nucleic acids complexes of two peptide nucleic acid stra

1995-06-07

1999-11-16

Houtteman, Scott W.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

514 44, 536 245, C07K 200

Patent

active

059860537

ABSTRACT:
Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.

REFERENCES:
patent: 5134066 (1992-07-01), Rogers et al.
Demidov, Vadim et al., "Sequence Selective Double Strand DNA Cleavage by Peptide Nucleic Acid (PNA) Targeting Using Nuclease S1" Nucl. Acids Res. 1993 21(19), 2103-2107.
Depto and Stenberg, "Regulated Expression of the Human Cytomegalovirus pp65 Gene: Octamer Sequence in the Promoter is Required for Activation by Viral Gene Products", J. of Virol. 1989, 63, 1232-1238.
Dubochet et al, "A New Preparation Method for Dark-Field Electron Microscopy of Biomacromolecules", J. Ultrastruct. Res. 1971, 35, 147-167.
Egholm, M. et al., "Peptide Nucleic Acids (PNA). Oligonucleotide Analogues with an Achiral Peptide Backbone", J. of the Am. Chem. Soc. 1992, 114, 1895-1897.
Egholm, M et al., "Peptide Nucleic Acids Containing Adenine and Guanine Recognize Thymine and Cytosine in Complementary DNA Sequences" J. Chem. Soc. Chem. Commun. 1993 800-801.
Froehler et al., "Oligodeoxynucleotides Containing C-5 Propyne Analogs of 2'-Deoxyuridine and 2'-Deoxycytidine", Tetrahedron Letters 1992, 33, 5307-5310.
Hahn, B.H. et al., "Molecular cloning and characterization of the HTLV-III virus associated with AIDS", Nature 1984, 312,166-169.
Lal et al., Diphenylphosphoryl Azide A Novel Reagent For The Stereospecific Synthesis of Azides From Alcohols, Tetrahedron Letters 1977, 23, 1977-1980.
McCurdy, S. et al., "Deoxyoligonucleotides Within Inverted Polarity: Synthesis and use inTriple-Helix Formation", Nucleosides & Nucleotides 1991, 10, 287-290.
Nielsen, P.E., et al., "Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide", Science 1991, 254, 1497-1500.
Sagi et al., "Base-Modified Oligodeoxynucleotides. I. Effect of 5-Alkyl,5-(1-Alkenyl) and 5-(Alkynyl) Substitution of the Pyrmidines on Duplex Stability and Hydrophobicity", Tetrahedron Letters 1993, 34, 2191-2194.
Spalholz et al., "Bovine Papillomavirus Transcriptional Regulation: Localization of the E2-Repsonsive Elements of the Long Control Region", J. Virol., 1987, 61, 2128-2137.
Stenberg, et al., "Promoter-specific trans activation and repression by Human Cytomegalovirus Immediate-early Proteins Involves Common and Unique Protein Domains", J. of Virology 1990, 64, 1556-1565.
Tibanyenda et al., "The effect of single base-pair mismatches on the duplex stability of d(T-A-T-T-A-A-T-A-T-C-A-A-G-T-T-G) d(C-A-A-C-T-T-G-A-T-A-T-T-A-A-T-A)", Eur. J. Biochem. 1984, 139, 19-27.
Vasseur, J. -J. et al., "Oligonucleosides; Synthesis of Novel Methylhydroxylamine-Linked Nucleoside Dimer and Its Incorporation into Antisense Sequences", J. Am. Chem. Soc. 1992, 114, 4006-4007.
Vickers, T. et al., "Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element", Nucleic Acids Research 1991, 19(12), 3359-3368.
Almarsson, O. et al., "Molecular Mechanics Calculations of the Structures of Polyamide Nucleic Acid DNA Duplexes and Triple Helical Hybrids" Proc. Natl. Acad. Sci. USA 1993, 90(16), 7518-7522.
Almarsson. O. et al., Peptide Nucleic Acid (PNA) Conformation and Polymorphism in PNA-DNA and PNA-RNA hybrids. Proc. Natl. Acad. Sci. USA 1993, 90(20), 9542-9546.
Brown et al., "NMR Solution Structure of a Peptide Nucleic Acid Complex with RNA" Science 1994, 265, 777-780.
Chen et al., "Molecular Dynamics and NMR Studies of Single-Stranded PNA's" Tetrahedron Lett. 1994, 35 (29), 5150-5108.
Demidov et al., "Stability of Peptide Nucleic Acides in Human Serum and Cellular Extracts" Biochem. Pharmacol. 1994, 48(6), 1310-1313.
Dueholm et al., "An Efficient Synthetic Approach to Boc-aminoacetaldehyde and Its Application in the Synthesis of 2-Boc-aminoethylglycine Methl Ester" Org. Prep. Proc. Int. 1993, 25, 457-461.
Dueholm et al., "Peptide Nucleic Acid (PNA) with a Chiral Backbone Based on Alanine" Bioorg. Med. Chem. Lett. 1994, 4(8), 1077-1080.
Dueholm et al., "Synthesis of Peptide Nucleic Acids Monomers Containing the Four Natural Nucleobases: Thymine, Cytosine, Adenine and Guanine, and Their Oligomerization", J. Org. Chem 1994, 59(19), 5767-5773.
Egholm et al., Recognition of Guanine and Adenine in DNA by Cytosine and Thymine Containing Peptide Nucleic Acids (PNA), J. Am. Chem. Soc. 1992, 114, 9677-9678.
Flam, F., "Can DNA Mimics Improve on the Real Thing?" Science 1993, 262, 1647-1649.
Frank-Kamenetskii, M., "A Change of Backbone" Nature 1991, 354, 505.
Griffith et al., "Single and Bis Peptide Nucleic Acids as Triplexing Agents: Binding and Stoichiometry" J. Am. Chem. Soc., 1995, 117(2), 831-832.
Hyrup et al. "Modification of the Binding Affinity of Peptide Nucleic Acids (PNA). PNA With Extended Backbones Consisting of 2-aminoethyl-B-alanine or 3-aminopropylglycine Units" J. Chem. Soc. Chem. Comm. 1993, 518-519.
Hyrup et al., "Structure-activity Studies of the Binding of Modified Peptide Nucleic Acids (PNA) to DNA" J. Am. Chem. Soc. 1994, 116(18), 7964-7970.
Kosynkina L. et al., "A Convenient Synthesis of Chiral Peptide Nucleic Acid (PNA) Monomers" Tetrahedron Lett. 1994, 35(29), 5173-5176.
Lagriffoul et al., "The Synthesis, Cooligomerization and Hybridization of a Thymine-thymine Heterodimer Containing PNA" Bioorg. Med. Chem. Lett. 1994, 4(8), 1081-1082.
Leijon et al., "Structural Characterization of PNA-DNA Duplexes by NMR. Evidence for DNA in a B-like Conformation" Biochemistry 1994, 33(33), 9820-9825.
Mollegaard et al., "Peptide Nucleic Acid-DNA Strand Displacement Loops as Artificial Transcription Promoters" Proc. Natl. Acad. Sci. USA 1994, 91(9), 3892-3895.
Nielsen et al., "Peptide Nucleic Acids (PNA). Potential Anti-Sense and Anti-Gene Agents" Anticancer Drug Des., 1993, 8(1), 53-63.
Nielsen, P.E., "Peptide Nucleic Acids (PNA): Potential Antiviral Agents" Int'l. Antiviral News 1993, 1, 37-39.
Nielsen et al., "Peptide Nucleic Acids (PNA). DNA Analogues with a Polyamide Backbone" Antisense Research and Applications, CRC Press, 1993, pp. 363-373.
Nielsen, P.E., "Peptide Nucleic Acid (PNA): A Model Structure for the Primordial Genetic Material" Orig. Life Evol. Biosph. 1993, 23(5-6), 323-327.
Nielsen et al., "Peptide Nucleic Acid (PNA). A DNA Mimic with a Peptide Backbone" Bioconjugate Chem. 1994, 5(1), 3-7.
Nielsen et al., "Sequence-specific Transcription Arrest by Peptide Nucleic Acid Bound to the DNA Template Strand", Gene 1994, 149(1), 139-145.
Orum et al., "Single Base Pair Mutation Analysis by PNA Directed PCR Clamping", Nucleic Acids Res. 1993, 21(23), 5332-5336.
Peffer et al., "Strand-Invasion of Duplex DNA by Peptide Nucleic Acid Oligomers" Proc. Natl. Acad. Sci. USA 1993, 90(22), 10648-10652.
Rose, D.J., "Characterization of Antisense Binding Properties of Peptide Nucleic Acids By Capillary Gel Electrophoresis" Anal. Chem. 1993, 65(24), 3545-3549.
Wittung et al., "DNA-like Double Helix Formed by Peptide Nucleic Acid" Nature 1994, 368, 561-563.

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