Peptide nucleic acid conjugates

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

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C530S323000, C530S350000, C536S023100, C536S024100, C536S024300, C536S024310, C536S024320, C536S024330, C536S025300

Reexamination Certificate

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08319411

ABSTRACT:
A novel class of peptide nucleic acids are described which include a conjugate attached thereto. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

REFERENCES:
patent: 4711955 (1987-12-01), Ward et al.
patent: 4879220 (1989-11-01), Mrsny et al.
patent: 4917800 (1990-04-01), Lonsdale et al.
patent: 5134066 (1992-07-01), Rogers et al.
patent: 5142047 (1992-08-01), Summerton et al.
patent: 5166315 (1992-11-01), Summerton et al.
patent: 5234579 (1993-08-01), Pasternak
patent: 5324483 (1994-06-01), Cody et al.
patent: 5539082 (1996-07-01), Nielsen et al.
patent: 5623049 (1997-04-01), L obberding et al.
patent: 5705333 (1998-01-01), Shah et al.
patent: 5719262 (1998-02-01), Buchardt et al.
patent: 5773571 (1998-06-01), Nielsen et al.
patent: 5786461 (1998-07-01), Buchardt et al.
patent: 5834607 (1998-11-01), Manoharan et al.
patent: 6395474 (2002-05-01), Buchardt et al.
patent: WO 86/05518 (1986-09-01), None
patent: WO 86/05519 (1986-09-01), None
patent: WO 90/02749 (1990-03-01), None
patent: WO 92/20702 (1992-11-01), None
patent: WO 92/20703 (1992-11-01), None
patent: WO 93/05180 (1993-03-01), None
patent: WO 93/07883 (1993-04-01), None
patent: WO 93/12129 (1993-06-01), None
patent: WO A93/12129 (1993-06-01), None
patent: WO 93/18052 (1993-09-01), None
patent: WO 94/06815 (1994-03-01), None
patent: WO 95/16202 (1995-06-01), None
patent: WO 95/32305 (1995-11-01), None
Suvityer et al., Biochemistry, vol. 32, No. 39, pp. 10489-10496, 1993.
Saito et al., Journal of the American Chemical Society, vol. 105, No. 23, pp. 6989-6991, 1983.
Finle et al., Analytical Biochemistry, vol. 108, pp. 394-401, 1980.
Soon et al., Biochemistry, vol. 26, pp. 7113-7121, 1987.
Mechanic et al., Biochimica et Biophysica Acta, vol. 393, pp. 419-425 (1975).
Fujii et al., FEBS Letters, vol. 97, No. 1, pp. 193-195 (1979).
Lehninger [Published by Worth Publishers, Inc., 70 Fifth Avenue, New York, NY 10011 (1970)], pp. 204 and 272.
Affinity Chromatography—A practical Approach, P.D.g. Dean, W.S. Johnson and F.A. Middle, eds., IRL Press Ltd., Oxford 1986.
Agrawal, S. and Tang, “Site-Specific Funcitonalization of Oligodeoxynucleotides for Non-Radioactive Labelling”,Tetrahedron Letters1990, 31 (11), 1543-1546.
Akashi, et al., “New Aspects of Polymer Drugs”,Adv. Polym. Sci.1990, 97, 108-146.
Aldrich Technical Bulletin Number AL-180, “Diazald®, MNNG and Diazomethane Generators”, 1990.
Anderson et al., “t-Butyloxycarbonylamino Acids and Their Use in Peptide Synthesis”,J. Am. Chem. Soc.1957, 79, 6180-6183.
Atherton et al., “The Fluorenylmethoxycarbonyl Amino Protecting Group”, The Peptides 9, 1987 1-38.
Atherton et al., “A Physically Supported Gel Polymer for Low Pressure, Continuous Flow Solid Phase Reactions. Application to Solid Phase Peptide Synthesis”,J. Chem. Soc. Chem. Commun1981, 1151-1152.
Atherton et al., “Polyamide Supports for Polypeptide Synthesis”,J. Am. Chem. Soc1975, 50, 6584-6585.
Atherton et al., “Peptide Synthesis. Part 2. Procedures for solid-phase Synthesis Using Nα—Fluorenylmethoxycarbonylamino-acids on Polyamide Supports. Synthesis of Substance P and of Acyl Carrier Protein 65-74 Decapeptide”,J. C. S. Perkin1981, I, 538-546.
Atherton, E. et al., “The Polyamide Method of Solid Phase Peptide and Oligonucleotide Synthesis”Bioorg. Chem.1979, 8, 351-370.
Baker, B., “Decapitation of a 5-capped oligoribonucleotide by o-phenanthroline:Cu (II) ”,J. Am. Chem. Soc.1993, 115, 3378-3379.
Barany et al., “Solid-phase Peptide Synthesis: a Silver Anniversary Report”,Int. J. Peptide Protein Res.1987, 30, 705-739.
Barany and Merrified in “The Peptides” vol. 2, Academic Press, N.Y., 1979, pp. 1-284.
Barany et al., “A New Amino Protecting Group Removable by Reduction. Chemistry of the Dithiasuccinoyl (Dts) Function”,J. Am. Chem. Soc.1977, 99, 7363-7365.
Barton et al., “Solid-Phase Synthesis of Selectively Protected Peptides for Use as Building Units in the Solid-Phase Synthesis of Large Molecules”,J. Am. Chem. Soc.1973, 95, 4501-4506.
Bayer and Jung, “A New Support for Polypeptide Synthesis in Columns”,Tetrahedron Lett1970, 51, 4503-4505.
Beaucage and Caruthers, “Deoxynucleoside Phosphoramidites-A New Class of Key Intermediates for Deoxypolynucleotide Synthesis”Tetrahedron Lett., 1981, 22, 1859-1862.
Bearn, Milo{hacek over (s)}et al., “Substituted ω—(4-Oxo-3, 4-Dihydro-5-Pyrimidinyl) Alkanoic Acids, Their Derivatives and Analogues”Collect. Czech. Chem. Commun.1983, 48, 292-298.
Berg et al., “Long-Chain Polystyrene-Grafter Polyethylene Film Matrix: A New Support for Solid-Phase Peptide Synthesis”,J. Am. Chem. Soc1989, 111, 8024-8026.
Blackwell, T. K. et al., “Sequence-Specific DNA Binding by the c-Myc protein,”Science1990, 250, 1149-1151.
Bodánzsky, “Synthesis of Peptides by Aminolysis of Nitrophenyl Esters”,Nature1955, 175, 685.
Bodanszky et al., “Active Esters and Resins in Peptide Synthesis”,Chem. Ind.1964, 1423-1424.
Bodanzsky, “Principles of Peptide Synthesis”, Springer Verlag, Berlin-New York 1984.
Brady et al., “Large-Scale Synthesis of a Cyclic Hexapeptide Analogue of Somatostatin,”J. Org. Chem.1987, 52, 764-769.
Brady et al., “Some Novel, Acid-Labile Amine Protecting Groups”,J. Org. Chem.1977, 42, 143-146.
Buttrey et al., “Synthetic Analogues of Polynucleotides-XIII: The Resolution of DL-β—(Thymin-1-YL)Alanine and Polymerisation of the β—(Thymin-1-YL)Alanines”,Tetrahedron1975, 31, 73-75.
Carpino, “New Amino-Protecting Groups in Organic Synthesis”,Acc. Chem. Res.1973, 6, 191-198.
Carpino “The 9-Fluorenylmethoxycarbonyl Amino-Protecting Group”J. Org. Chem., 1972, 37, 3404-3409.
Carpino, “Oxidative Reactions of Hydrazines. IV. Elimination of Nitrogen from 1, 1-Disubstituted-2-arenesulfonhydrazides1-4”,J. Am. Chem. Soc.1957, 79, 4427-4431.
Carpino and Han, “The 9-Fluorenylmethoxycarbonyl Function, a New Base-Sensitive Amino-Protecting Group”,J. Am. Chem. Soc.1970, 92, 5748-5749.
Carpino et al., “((9-Fluorenylmethyl) oxy) carbonyl (FMOC) Amino Acid Fluorides. Convenient New Peptide Coupling Reagents Applicable to the FMOC/tert-Butyl Strategy for Solution and Solid-Phase Syntheses”,J. Am. Chem. Soc.1990, 112. 9651-9652.
Caruthers, Marvin H., “Gene Synthesis Machines: DNA Chemistry and Its Uses”Science, 1985, 232, 281-285.
Chiang et al., “Antisense Oligonucleotides Inhibit Intercellular Adhesion Molecule 1 Expression by Two Distinct Mechanisms”,J.Biol.Chem., 1991, 266:18162-18171.
Corey et al., “Generation of a Hybrid Sequence-Specific Single-Stranded Deoxyribonuclease”,Science, 1987, 238:1401-1403.
Cullen, B., “The HIV-1 Tat Protein: An RNA Sequence-Specific Processivity Factor?”Cell1990, 63, 655-657.
Daniels et al., “Membranes as Solid Supports for Peptide Synthesis”,Tetrahedron Lett.1989, 30, 4345-4348.
Delgado et al., “The Uses and Properties of PEG-Linked Proteins”,Critical Reviews in Therapeutic Drug Carrier Systems.1992, 9, 249-304.
Demidov, V. et al., “Sequence Selective Double Strand DNA Cleavage by Peptide Nucleic Acid (PNA) Targeting Using Nuclease S1”Nucl. Acids Res.1993 21(19), 2103-2107.
Depto et al., “Regulated Expression of the Human Cytomegalovirus pp65 Gene: Octamer Sequence in the Promoter Is Required for Activation by Viral Gene Products,”J. Virol.1989, 63, 1232-1238.
Dizio et al., “Progestin-Rhenium Complexes: Metal-Labled Steroids with High Receptor Binding Affinity, Potential Receptor-Directed Agents for Diagnostic Imaging or Therapy”,Bioconjugate Chem., 1991, 2, 353-366.
Doel et al., “An

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