Peptide modulation of reperfusion injury

Details Peptide modulation of reperfusion injury Peptide modulation of reperfusion injury

1998-02-16

2000-10-17

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 12, 514 13, 514 14, 514 18, 530324, 530330, A61K 3816

Patent

active

06133233&

ABSTRACT:
An in vivo method of reducing reperfusion injury in a mammal resulting from reperfusion of a temporarily occluded blood vessel which comprises the steps of administering into the mammal's bloodstream an effective amount of a proline /arginine rich peptide such as PR-39 (SEQ ID NO: 1). The method has particular application in surgical procedures such as coronary bypass and organ transplantation surgery and where reperfusions occur subsequent to a spontaneous occlusion. Preferred peptides have up to about 50 amino acid residues with a plurality of --PXXP-- sequences.

REFERENCES:
patent: 5489575 (1996-02-01), Lee et al.
patent: 5633229 (1997-05-01), Kokryakov et al.
patent: 5654273 (1997-08-01), Gallo et al.
Ginis, I. et al. J. Cell. Physiol., 157: 569-578, Mar. 1993.

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