Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1993-11-24
1995-05-30
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
530300, 530333, A61K 3800, C07K 500, C07K 700, C07K 1400
Patent
active
054202469
ABSTRACT:
A method to obtain selected individual peptides or families thereof which have a target property and optionally to determine the amino acid sequence of a selected peptide or peptides to permit synthesis in practical quantities is disclosed. In general outline, the method of the invention comprises synthesizing a mixture of randomly or deliberately generated peptides using standard synthesis techniques, but adjusting the individual concentrations of the components of a mixture of sequentially added amino acids according to the coupling constants for each amino acid/amino acid coupling. The subgroup of peptides having the target property can then be selected, and either each peptide isolated and sequenced, or analysis performed on the mixture to permit its composition to be reproduced. Also included in the invention is an efficient method to determine the relevant coupling constants.
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Furka, A. Sebestyen, F., Asgedom, M., Dibo, G., More Peptides by Less Labour, Abstract, 10th International Symposium on Medicinal Chemistry, Budapest.
Furka, A., Sebestyen, F., Oulyon, J., Computer Made Electrophoretic Peptide Maps, 2nd International Conference on Biochemical Separations, Keszthely.
Furka, A., Sebestyen, F., Asgedom, M., Dibo, G., General method for rapid synthesis of multicomponent peptide mixtures, Int. J. Peptide Res. 37:487-493.
Rutter William J.
Santi Daniel V.
Bozicevic Karl
Prickril Benet
Schain Howard E.
The Regents of the University of California
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