Peptide mimics useful as platelet aggregation inhibitors

Details Peptide mimics useful as platelet aggregation inhibitors Peptide mimics useful as platelet aggregation inhibitors

1995-05-18

1996-08-27

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

562440, A61K 31195

Patent

active

055501591

ABSTRACT:
This invention relates to compounds having the following formula ##STR1## or pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions of such phenylamidines derivatives, and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.

REFERENCES:
patent: 5053392 (1991-10-01), Klein et al.
patent: 5239113 (1993-08-01), Bovy, et al.
patent: 5272162 (1993-12-01), Tjoeng et al.
patent: 5273982 (1993-12-01), Alig et al.
patent: 5314902 (1994-05-01), Tjoeng et al.
patent: 5344957 (1994-09-01), Bovy et al.
patent: 5354738 (1994-10-01), Tjoeng et al.
U.S. application Ser. No. 07/777,811, filed Oct. 15, 1991, Bovy.
R. Ferroni, et al. "Ethyl esters of N-amidinobenzoyl amino acids: inhibitory effects on thrombin, blood coagulation, and platelet aggregation", Chemical Abstracts, vol. 108, p. 17, No. 48724q, (1988).
T. Yokoyama, et al. "New synthetic inhibitors of chymotrypsin, trypsin, thrombin, plasmin, urokinase, tissue plasminogen activator, factor Xa, tissue kallikrein, and plasma kallikrein", Chemical Abstracts, vol. 107, p. 361, No. 193882y, (1987).
J. Stuerzebecher, et al. "Synthetic inhibitors of serine proteinases. Part 32: Inhibition of trypsin, plasmin, and thrombin by amides of N-alpha-substituted-4-amidinophenylalanine. Influence of various amino acids and blocking groups of the N-alpha-residue on the inhibitory activity", Chemical Abstracts, vol. 107, p. 327, No. 92532d, (1987).
B. Voigt, et al. "Synthesis of N-alpha-benzyloxycarbonyl-4-amidino-phenylalanine amides as thrombin inhibitors", Chemical Abstracts, vol. 104, p. 603, No. 186094c, (1986).
J. Stuerzebecher, et al. "Synthetic inhibitors of serine proteinases. 13. Quantitative structure-activity relations for inhibition of trypsin, plasmin, and thrombin by 4-amidinophenyl compounds with a keto group", Chemical Abstracts, vol. 87, p. 19, No. 62379k, (1977).
U.S. application Ser. No. 08/138,559, filed Oct. 15, 1993, Bovy, et al.
U.S. application Ser. No. 08/019,923, filed Feb. 19, 1993, Tjoeng, et al.
Hartman, et al. "Non-peptide Fibrinogen Receptor Antagonists. 1. Discovery and Design of Exosite Inhibitors", J. Med. Chem., vol. 35, pp. 4640-4642 (1992).

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