Peptide mimetic compounds useful as platelet aggregation inhibit

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

560 13, 560 35, 562440, 562623, 558414, 546332, 564147, 564163, 549 58, 549 77, 549441, 514539, 514533, 514542, 514563, 514438, 514443, 514468, C07C22900

Patent

active

052200507

ABSTRACT:
This invention relates to having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidines derivatives.

REFERENCES:
patent: 4517686 (1985-05-01), Ruoslahti et al.
patent: 4578079 (1986-03-01), Ruoslahti et al.
patent: 4589881 (1986-05-01), Pierschbacher et al.
patent: 4614517 (1986-09-01), Ruoslahti et al.
patent: 4661111 (1987-04-01), Ruoslahti et al.
patent: 4683291 (1987-07-01), Zimmerman et al.
patent: 4791102 (1988-12-01), Bernat et al.
patent: 4857508 (1989-08-01), Adams et al.
patent: 4879313 (1989-11-01), Tjoeng et al.
patent: 4977168 (1990-12-01), Bernat et al.
Kloczewiak, et al., Biochem., 23, 1767-1774 (1984).
Ruggeri, et al., Proc. Natl. Acad. Sci., 83, 5708-5712 (1986).
Plow, et al., Proc. Natl. Acad. Sci., 82, 8057-8061 (1985).
Ginsberg, et al., J. Biol. Chem., 260, (7), 3931-3936 (1985).
Haverstick, et al., Blood, 66, (4), 946-952 (1985).
Ruoslahti and Pierschbacher, Science, 238, 491-497 (1987).
R. Ferroni, et al. "Ethyl Esters of N-Amidinobenzoyl Amino Acids: Inhibitory Effects on Thrombin, Blood Coagulation, and Platelet Aggregation," Farmaco, Ed. Sci., vol. 42, No. 10, pp. 709-715, 1987.
T. Yokoyama, et al. "New Synthetic Inhibitors of Chymotrypsin, Thrypsin, Thrombin, Plasmin, Urokinase, Tissue Plasminogen Activator, Factor Xa, Tissue Kallikrein, and Plasma Kallikrein," Jap. J. Clin. Chem., vol. 15, No. 6, pp. 338-344, 1986.
J. Stuerzebecher, et al. "Synthetic Inhibitors of Serine Proteinases, Part 32--Inhibition of Trypsin, Plasmin and Thrombin by Amides of Amino Acids and Blocking Groups of the N-Alpha-Residue On the Inhibitor Activity," Pharmazie, vol. 42, No. 2, pp. 114-116, 1987.
B. Voight, et al. "Synthesis of N-Alpha-Benzyloxycarbonyl-amidino-phenylalanine Amide as Thrombin Inhibitors," Pharmazie, vol. 40, No. 5, pp. 305-306, 1985.
J. Stuerzebecher, et al. "Synthetic Inhibitors of Serine Proteases, 13.Quantitative Structure-Activity Relations for Inhibition of Trypsin, Plasmin, and Thrombin by 4-amidino-phenyl Compounds with a Keto Group," Acta. Biol. Med. Ger., vol. 35, No. 12, pp. 1665-1676, 1976.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Peptide mimetic compounds useful as platelet aggregation inhibit does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptide mimetic compounds useful as platelet aggregation inhibit, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide mimetic compounds useful as platelet aggregation inhibit will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1044483

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.