Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1992-02-20
1995-08-22
Geist, Gary
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 9341, 424 942, A61K 4900, A61K 5108
Patent
active
054438160
ABSTRACT:
Peptides containing a biological-function domain and a medically useful metal ion-binding domain are labeled with medically useful metal ions for use in diagnosis and treatment of a variety of pathologic conditions. The peptides have the amino acid sequence
REFERENCES:
patent: 3812264 (1974-05-01), Nouel
patent: 4424200 (1984-01-01), Crockford et al
patent: 4427646 (1984-01-01), Olexa et al.
patent: 4434151 (1984-02-01), Byrne et al.
patent: 4444690 (1984-04-01), Fritzberg
patent: 4455290 (1984-06-01), Olexa et al.
patent: 4472509 (1984-09-01), Gansow et al.
patent: 4479930 (1984-10-01), Hnatowich
patent: 4485101 (1984-11-01), Coy et al.
patent: 4571430 (1986-02-01), Byrne et al.
patent: 4575556 (1986-03-01), Byrne et al.
patent: 4668503 (1987-05-01), Hnatowich
patent: 4732864 (1988-03-01), Tolman
patent: 4810693 (1989-03-01), Pickart
patent: 4853371 (1989-08-01), Coy et al.
patent: 4861869 (1989-08-01), Nicolotti et al.
patent: 4871717 (1989-10-01), Coy et al.
patent: 4877868 (1989-10-01), Reno et al.
patent: 4904642 (1990-02-01), Coy et al.
patent: 4986979 (1991-01-01), Morgan, Jr. et al.
patent: 5011676 (1991-04-01), Thakur
patent: 5011916 (1991-04-01), Bonnyman et al.
patent: 5023237 (1991-06-01), Pickart
patent: 5053493 (1991-10-01), Pak et al.
patent: 5059588 (1991-10-01), Pickart
patent: 5061641 (1991-10-01), Shochat et al.
patent: 5078985 (1992-01-01), Rhodes
patent: 5102990 (1992-04-01), Rhodes
patent: 5116596 (1992-05-01), Bremer
patent: 5128119 (1992-07-01), Griffiths
patent: 5200504 (1993-04-01), Ghadiri
Albert et al., J. Nucl. Med., vol. 31 (1990) Abstract, "A Somatostatin Analogue to Image . . . ".
Kwekkeboom et al., J. Nucl. Med., vol. 32 (1991) Abstract, "[1n-III-DTPA-D-Phe]-Octreotide Scintigraphy . . .", p. 981.
Cox et al., 7th International Symposium on Radiopharmacology, (1991) "Techetium Labeled Somatostatin . . . " p. 16.
Tubis et al., Int. J. Appl. Rad. and Isotopes, vol. 19, (1968) pp. 835-840.
"The Labeling of High Affinity Sites of Antibodies with 99mTc," by Chiang H. Paik et al., Int. J. Nucl. Med. Biol., vol. 12, No. 1, pp. 3-8 (1985).
"Technetium-99m Labeling of Murine Monoclonal Antibody Fragments," by Buck A. Rhodes et al., J. Nucl. Med., vol. 27, No. 5, pp. 685-693 (May 1986).
Arnold, Frances H., et al., "Engineered Metal-Binding Proteins: Purification to Protein Folding," Science, vol. 152, pp. 1796-1797 (Jun. 28, 1991) Cioce, Vittoria, et al., Increased Expression of the Laminin Receptor in Human Colon Cancer, Articles, Journal of National Cancer Institute, vol. 83, No. 1, pp. 29-36 (Jan. 2, 1991).
Castronovo, Vincent, et al., "Laminin Receptor Complementary DNA-deduced Synthetic Peptide Inhibits Cancer Cell Attachment to Endothelium," Cancer Research, vol. 51, pp. 5672-5678 (Oct. 15, 1991).
Fischman, Alan J., et al., "Imaging Focal Sites of Bacterial Infection in Rats with Indium-111-Labeled Chemotactic Peptide Analogs," Journal of Nucl. Med., vol. 32, No. 3, pp. 483-491 (Mar. 1991).
Ghadiri, M. Reza, et al., "Peptide Architecture, Design of Stable .alpha.-Helical Metallopeptides via a Novel Exchange-Insert Ru.sup.III Complex," J. Am. Chem. Soc., vol. 112, No. 26, pp. 9633-9635 (1990).
Hynes, Richard O., "Integrins: A Family of Cell Surface Receptors," Review, Cell, vol. 48, pp. 549-554 (1987).
Iverson, Brent L., et al., "Metalloantibodies," Reports, Science, vol. 249, pp. 659-662 (Aug. 1990).
Janeczek, Amelia H., et al., "Autoradiographic analysis of formylpeptide chemoattractant binding, uptake and intracellular processing by neutrophils," Journal of Cell Science, vol. 94, pp. 155-168 (1989).
Kwekkeboom, Dirk J., et al., "Radioiodinated Somatostatin Analog Scintigraphy in Small-Cell Lung Cancer," Journal of Nucl. Med., vol. 32, No. 10, pp. 1845-1848 (Oct. 1991).
Seifert, S., et al., "Technetium-99 and 99m chelates with N-donor ligands: a new class of potential cationic radiopharmaceuticals," Technitium in Chemistry and Nuclear Medicine, E. Deutsch, M. Nicolini, H. N. Wagner, Jr., eds., Cortina International, Verona, pp. 19-23 (1983).
Sonnenberg, Arnoud, et al., "Laminin receptor on platelets is the integrin VLA-6", Nature, vol. 336, pp. 487-489 (Dec. 1988).
Tandon, Narendra N., et al., "Interaction of human platelets with laminin and identification of the 67 kDa laminin receptor on platelets," Biochem. J., vol. 274, pp. 535-542 (1991).
Thompson, H. L., et al., "Identification of an amino acid sequence in the laminin A chain mediating mast cell attachment and spreading," Immunol., vol. 72, pp. 144-149 (1991).
Vallee, Bert L., et al., "Zinc Coordination, Function, and Structure of Zinc Enzymes and Other Proteins," Biochemistry, vol. 29, No. 24, pp. 5647-5659 (Jun. 19, 1990).
R. Albert, et al., "A Somatostatin Analogue to Image SS-Receptor-Positive Tumours": [.sup.111 In-DTPA-DPhe].sup.1 -Octreotide (SDZ 215-811), 12th American Peptide Symposium, Abstract LM10, 1991.
W. H. Bakker, et al., "In Vivo Use of a Radioiodinated Somatostatin Analogue: Dynamics, Metabolism, and Binding to Somatostatin Receptor-Positive Tumors in Man," The Journal Of Nuclear Medicine, vol. 32, No. 6, pp. 1184-1191, 1991.
W. H. Bakker, et al., "Receptor Scintigraphy witha Radioiodinated Somatostatin Analogue: Radiolabeling, Purification, Biologic Activity, and In Vivo Application in Animals," The Journal of Nuclear Medicine, vol. 31, pp. 1501-1509, 1990.
D. W. Cox, et al., "Technetium Labelled Somatostatin a Potential Agent for In Vivo Tumour Localisation," 7th International Symposium on Radiopharmacology, Abstract, p. 16, 1991.
A. Davidson, et al., "A New Class of Oxotechnetium (5+) Chelate Complexes Containing a TcON.sub.2 S.sub.2 Core," Ingor. Chem., vol. 20, No. 6, 1981.
A. R. Fritzberg, et al., "Synthesis and Biological Evaluation of Tc-99m N,N'-Bis(mercaptoacetyl)-2,3-diaminopropanoate: A Potential Replacement for [.sup.131 :]o-iodohippurate," The Journal of Nuclear Medicine, vol. 23, pp. 592-598, 1982.
B. A. Khaw, et al., "Technetium-99m Labeling of Antibodies to Cardiac Myosin Fab and to Human Fibronogen," The Journal of Nuclear Medicine, vol. 23, pp. 1011-1019, 1982.
D. J. Kwekkeboom, et al., "_.sup.In-111-DTPA-D-Phe _.sub.1 -Octreotide Scintigraphy in Neuro-Endocrine Tumors," The Journal of Nuclear Medicine, vol. 32, No. 5, p. 981, 1991.
B. A. Rhodes, "Considerations in the Radiolabeling of Albumin," Seminars in Nuclear Medicine, vol. 4, No. 3, pp. 281-293, 1974.
N. Bryson et al., "Neutral Technetium (V) Complexes with Amide-Thiol-Thioether Chelating Ligands," Inorg. Chem., vol. 27, pp. 2154-2161, 1988.
N. Bryson, et al., "Protecting Groups in the Preparation of Thiolate Complexes of Technetium," Inorg. Chem., vol. 29, pp. 2948-2951, 1990.
E. F. Byrne, et al., "Technetium-99m Bifunctional Chelating Agent--Thiolacctone for Coupling to Biomolecules, N.sub.2 S2 Ligand for Chelation to Technetium," The Journal of Nuclear Medicine, vol. 24, P126, 1983.
Rhodes Buck A.
Zamora Paul O.
Chapman Lara E.
Geist Gary
Peacock Deborah A.
RhoMed Incorporated
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