Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1995-05-31
1998-06-02
Kight, John
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 111, 424 165, 530300, 534 10, A61K 5100, A61M 3614
Patent
active
057595160
ABSTRACT:
Peptides containing a biological-function domain and a medically useful metal ion-binding domain are labeled with medically useful metal ions for use in diagnosis and treatment of a variety of pathologic conditions. The peptides have the amino acid sequence
and !.sub.n, in which n is a number between 1 and about 6 and Y.sub.1 and Y.sub.2 are amino acids with a sulfur, nitrogen or oxygen which is available for binding to metal ions, or can be made available for binding to metal ions; the biological-function domain is an amino acid sequence containing from 1 to about 20 amino acids located in any one or more of R.sub.1, R.sub.2 or R.sub.3 ; and those portions of R.sub.1, R.sub.2 and R.sub.3 which are not part of the biological-function domain are amino acid sequences containing from 0 to about 20 amino acids. The resulting product may be stored frozen or lyophilized, with labeling accomplished by the addition of the medically useful metal ions. The medically useful metal ion may be radioactive or paramagnetic, with diagnosis performed by gamma scintigraphy, specific photon emission computerized tomography, positron emission tomography or magnetic resonance imaging.
REFERENCES:
patent: 3812264 (1974-05-01), Nouel
patent: 4424200 (1984-01-01), Crockford et al.
patent: 4427646 (1984-01-01), Olexa et al.
patent: 4434151 (1984-02-01), Byrne et al.
patent: 4444690 (1984-04-01), Fritzberg
patent: 4455290 (1984-06-01), Olexa et al.
patent: 4472509 (1984-09-01), Gansow et al.
patent: 4479930 (1984-10-01), Hnatowich
patent: 4485101 (1984-11-01), Coy et al.
patent: 4571430 (1986-02-01), Byrne et al.
patent: 4575556 (1986-03-01), Byrne et al.
patent: 4668503 (1987-05-01), Hnatowich
patent: 4732864 (1988-03-01), Tolman
patent: 4810693 (1989-03-01), Pickart
patent: 4822606 (1989-04-01), Snyderman et al.
patent: 4853371 (1989-08-01), Coy et al.
patent: 4861869 (1989-08-01), Nicolotti et al.
patent: 4871717 (1989-10-01), Coy et al.
patent: 4877868 (1989-10-01), Reno et al.
patent: 4904642 (1990-02-01), Coy et al.
patent: 4986979 (1991-01-01), Morgan, Jr. et al.
patent: 4988496 (1991-01-01), Srinlvasan et al.
patent: 5011676 (1991-04-01), Thakur
patent: 5011916 (1991-04-01), Bonnyman et al.
patent: 5023237 (1991-06-01), Pickart
patent: 5053493 (1991-10-01), Pak et al.
patent: 5059588 (1991-10-01), Pickart
patent: 5061641 (1991-10-01), Shochat et al.
patent: 5078985 (1992-01-01), Rhodes
patent: 5102990 (1992-04-01), Rhodes
patent: 5116596 (1992-05-01), Bremer
patent: 5118791 (1992-06-01), Burnier et al.
patent: 5128119 (1992-07-01), Griffiths
patent: 5190920 (1993-03-01), Eyal et al.
patent: 5328840 (1994-07-01), Coller
patent: 5330911 (1994-07-01), Hubbell et al.
patent: 5376356 (1994-12-01), Morgan, Jr.
patent: 5443815 (1995-08-01), Dean et al.
patent: 5443816 (1995-08-01), Zamora et al.
patent: 5460785 (1995-10-01), Rhodes et al.
patent: 5556609 (1996-09-01), Zamora
patent: 5567408 (1996-10-01), Zamora
Babich et al (1993). Technetium--99m Labeled Hydrazino Nicotinamide Derivatized Chemotactic Peptide Analog for Imaging Focalsites of Bacterial Infection. J. Nucl. Med., vol. 34, No. 11, pp. 1964-1974.
Zamora et al (1993). Biological Distribution of 99m--Tc Labeled YIGSR and IKVAV Laminin Peptides in Rodents: 99m-Tc-IKVAV Peptide Localizes to the Lungs. Biochim. Biophys. Acta, vol. 1182, No. 2, pp. 197-204.
Zamora et al (1992). Imidazdes as Well as Thioates in Proteins Bind Technetium--99m Bioconjugate Chemistry, vol. 3, No. 6, pp. 493-498.
N. Bryson, et al., "Neutral Technetium (V) Complexes with Amide-Thiol-Thioether Chelating Ligands," Inorg. Chem., vol. 27, pp. 2154-2161, 1988.
N. Bryson, et al., "Protecting Groups in the Preparation of Thiolate Complexes of Technetium," Inorg. Chem., vol. 29, pp. 2948-2951, 1990.
E.F. Byrne, et al., "Technetium--99m Bifunctional Chelating Agent--Thiolacctone for Coupling to Biomolecules, N.sub.2 S2 Ligand for Chelation to Technetium," The Journal of Nuclear Medicine, vol. 24, p. 126, 1983.
D.W. Cox, et al., "Technetium Labelled Somatostatin a Potential Agent for In Vivo Tumour Localisation," 7th International Symposium on Radiopharmacology, Abstract, p. 16, 1991.
A. Davidson, et al., "A New Class of Oxotechnetium (5+) Chelate Complexes Containing a TcON.sub.2 S.sub.2 Core," Ingor. Chem., vol. 20, No. 6, 1981.
A. R. Fritzberg, et al., "Synthesis and Biological Evaluation of Tc--99m N,N'-Bis(mercaptoacetyl)-2,3-diaminopropanoate: A Potential Replacement Medicine, vol. 23, pp. 592-598, 1982.
B.A. Khaw, et al., "Technetium--99m Labeling of Antibodies to Cardiac Myosin Fab and to Human Fibrinogen," The Journal of Nuclear Medicine, vol. 23, pp. 1011-1019, 1982.
D.J. Kwekkeboom, et al., ".vertline..sup.In-111-DTPA-D-Phe .vertline..sub.1 -Octreotide Scintigraphy in Neuro-Endocrine Tumors," The Journal of Nuclear Medicine, vol. 32, No. 5, p. 981, 1991.
B.A. Rhodes, "Considerations in the Radiolabeling of Albumin," Seminars in Nuclear Medicine, vol. 4, No. 3, pp. 281-293, 1974.
"The Labeling of High Affinity Sites of Antibodies with 99mTc," by Chang H. Paik et al., Int. J. Nucl. Med. Biol., vol. 12, No. 1, pp. 3-8 (1985).
"Technetium--99m Labeling of Murine Monoclonal Antibody Fragments," by Buck A. Rhodes et al., J. Nucl. Med., vol. 27, No. 5, pp. 685-693 (May 1986).
Arnold, Frances H., et al., "Engineered Metal-Binding Proteins: Purification to Protein Folding," Science, vol. 252, pp. 1796-1797 (Jun. 28, 1991) Cioce, Vittoria, et al., Increased Expression of the Laminin Receptor in Human.
Castronovo, Vincent, et al., "Laminin Receptor Complementary DNA-deduced Synthetic Peptide Inhibits Cancer Cell Attachment to Endothelium," Cancer Research, vol. 51, pp. 5672-5678 (Oct. 15, 1991).
Colon Cancer, Articles, Journal of National Cancer Institute, vol. 83, No. 1, pp. 29-36 (Jan. 2, 1991).
Fischman, Alan J., et al., "Imaging Focal Sites of Bacterial Infection in Rats with Indium-111-Labeled Chemotactic Peptides Analogs," Journal of Nucl. Med., vol. 32, No. 3, pp. 483-491 (Mar. 1991).
Ghadiri, M. Reza, et al., "Peptide Architecture, Design of Stable .alpha.-Helical Metallopeptides via a Novel Exchange-Inert Ru.sup.III Complex," J. Am. Chem. Soc., vol. 112, No. 26, pp. 9633-9635 (1990).
Hynes, Richard O., "Integrins: A Family of Cell Surface Receptors," Review, Cell, vol. 48, pp. 549-554 (1987).
Iverson, Brent L., et al., "Metalloantibodies," Reports, Science, vol. 249, pp. 659-662 (Aug. 1990).
Janeczek, Amelia H., et al., "Autoradiographic analysis of formylpeptide chemoattractant binding, uptake and intracellular processing by neutrophils," Journal of Cell Science, vol. 94, pp. 155-168 (1989).
Kwekkeboom, Dirk J., et al., "Radioiodinated Somatostatin Analog Scintigraphy in Small-Cell Lung Cancer," Journal of Nucl. Med., vol. 32, No. 10, pp. 1845-1848 (Oct. 1991).
Seifert, S., et al., "Technetium--99m and 99m chelates with N-donor ligands: a new class of potential cationic radiopharmaceuticals," Technitium in Chemistry and Nuclear Medicine, E. Deutsch, M. Nicolini, H.N. Wagner, Jr., eds., Cortina International, Verona, pp. 19-23 (1983).
Sonnenberg, Arnoud, et al., Laminin receptor on platelets is the integrin VLA-6, Nature, vol. 336, pp. 487-489 (Dec. 1988).
Tandon, Narendra N., et al., "Interaction of human platelets with laminin and identification of the 67 kDa laminin receptor on platelets," Biochem. J., vol. 274, pp. 535-542 (1991).
Thompson, H.L., et al., "Identification of an amino acid sequence in the laminin A chain mediating mast cell attachment and spreading," Immunol., vol. 72, pp. 144-149 (1991).
Vallee, Bert L., et al., "Zinc Coordination, Function, and Structure of Zinc Enzymes and Other Proteins," Biochemistry, vol. 29, No. 24, pp. 5647-5659 (Jun. 19, 1990).
W.H. Bakker, et al., "In Vivo Use of a Radioiodinated Somatostatin Analogue: Dynamics, Metabolism, and Binding to Somatostatin Receptor-Positive Tumors in Man," The Journal of Nuclear Medicine, vol. 32, No. 6, pp. 1184-1191, 1991.
W.H. Bakker, et al., "Receptor Scintigraphy with a Radioiodinated Somatostatin Analogue: Radiolabeling, Purification, Biologic Activity, and In Vivo Application in Animals," T
Rhodes Buck A.
Zamora Paul O.
Jones Dameron
Kight John
RhoMed Incorporated
LandOfFree
Peptide-metal ion pharmaceutical preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Peptide-metal ion pharmaceutical preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide-metal ion pharmaceutical preparation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1456451