Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1998-03-13
1999-10-12
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 165, 424 111, 534 14, 534 10, 530300, 530311, A61K 5100, A61M 3614
Patent
active
059651083
ABSTRACT:
This invention relates to diagnostic and radiodiagnostic agents, including radiolabeled scintigraphic imaging agents, and therapeutic and radiotherapeutic agents. The invention provides such agents and reagents for preparing such agents, and methods for producing and using such reagents. Specifically, the invention provides radiolabeled imaging agents and non-radioactively labeled imaging agents for imaging sites in a mammalian body and reagents for preparing these imaging agents. The invention also provides radiolabeled therapeutic agents, as well as non-radioactively labeled therapeutic agents, and reagents and methods for preparing these agents. The agents and reagents provided comprise a specific binding peptide, covalently linked to a metal ion-complexing moiety. Reagents, methods and kits for making such reagents, methods for labeling such reagents, and methods for using such labeled reagents are provided.
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patent: 5556939 (1996-09-01), Flanagan et al.
patent: 5783170 (1998-07-01), Dean
Pearson, et al., (1996) "Somatostatin Receptor-Binding Peptides Labeled with Technetium-99m,: Chemistry and Initial Biological Studies" Jnl. Med. Chem., 39, 1361-1371.
Spanevello, et al., (1991) "Synthesis of Novel, Highly Potent Cyclic-Hexapeptide Analogs of Somatostatin. Potential Application of Orthogonal Protection for Affinity Chromatography" Tetrahedron Letter, vol. 32, No. 36, 4673-4678.
Dees Jos,e G.
Diatide, Inc.
Jones Dameron
McDaniels Patricia A.
Noonan Kevin E.
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