Peptide medicaments for the treatment of disease

Details Peptide medicaments for the treatment of disease Peptide medicaments for the treatment of disease

1992-09-09

1994-08-23

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 530324, 530325, A61K 3700, C07K 500

Patent

active

053408004

ABSTRACT:
Peptide medicaments, and antibody thereto, useful for treating or preventing diseases, particularly diseases involving an inflammatory response by a host organism against infection, that are preferably derived from the .beta. subunit, CD18, of the leukocyte integrins, and that have the property of either interfering with, or preventing undesirable leukocyte adhesion to biological materials, particular to endothelial cells, or that interfere with, or prevent the chemotaxis of leukocytes through the endothelial cell monolayer, consequently minimizing undesirable cell/tissue leukocyte binding and thus preventing or minimizing diseases resulting therefrom.

REFERENCES:
patent: 4797277 (1989-01-01), Arfors
Rudinger, Peptide Hormones (Jun. 1976) 1, 5-6.
Kishimoto et al. Cell vol. 48, 681 (Feb. 1987).
Kishimoto et al. Adv. In. Immun. vol. 46 (1989) ATIJO.
Abbas et al. Cell. & Mol. Immun (1991) at 158.
Hogg, N., 1989, Letters, pp. 111-114.

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