Peptide marker targeting to nasopharyngeal carcinoma cell...

Details Peptide marker targeting to nasopharyngeal carcinoma cell... Peptide marker targeting to nasopharyngeal carcinoma cell...

2007-07-03

2007-07-03

Foley, Shanon (Department: 1642)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S324000, C530S327000, C530S328000

Reexamination Certificate

active

10796892

ABSTRACT:
The present invention provides a peptide marker targeting to nasopharyngeal carcinoma (NPC) cells and application thereof. The peptide binds specifically to the cell surface of NPC cells. After conjugated with liposome containing chemotherapeutic drugs, such peptides deliver chemotherapeutic drugs to the tumor cells specifically and destruct tumor cells without damaging normal tissues and organs. Furthermore, such peptide is applied as a detector in the development of NPC diagnosis kit.

REFERENCES:
patent: 6372720 (2002-04-01), Longmuir et al.
patent: 2002/0172711 (2002-11-01), Martin et al.
patent: WO 200100225 (2001-01-01), None
patent: WO 200181581 (2001-11-01), None
Burgess et al. (J. Cell Biol. 111:2129-2138, 1990).
Wen et al. (Proc. Natl. Acad. Sci. U.S.A. 98: 4622-4627, 2001).
Lazar et al. ( Mol. Cell Biol. 8:1247-1252, 1998).
Kunisawa et al. (J. Controlled Release 2005; 105: 344-353).
Vaage et al. (Cancer; 1994: 73; 1478-1484).

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