Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1992-12-15
1996-11-12
Fleisher, Mindy
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 241, 536 256, 530300, C07H 2104, C07K 400
Patent
active
055741428
ABSTRACT:
A covalently linked conjugate of an oligonucleotide (ODN) with a peptide and a carrier or targeting ligand (ODN-peptide-carrier) includes a therapeutic oligonucleotide which is capable of selectively binding to a target sequence of DNA, RNA or protein inside a target cell. The ODN is covalently linked to a peptide which is capable of being cleaved by proteolytic enzymes inside the target cell. The peptide, in turn is covalently linked to a carrier or targeting ligand moiety which facilitates delivery of the entire ODN-peptide-carrier conjugate into the cell, and preferably into a specific target tissue type. Inside the cell, the peptide is cleaved, releasing the ODN which, by binding to the target DNA, RNA or protein sequence, brings about a beneficial result.
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Gall Alexander A.
Meyer, Jr. Rich B.
Reed Michael W.
Carter Philip W.
Fleisher Mindy
Microprobe Corporation
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