Peptide ligands which bind to von willebrand factor

Details Peptide ligands which bind to von willebrand factor Peptide ligands which bind to von willebrand factor

1995-09-22

1997-11-18

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

530381, 530413, 530383, C07K 704, C07K 1700, A61K 3514

Patent

active

056889127

ABSTRACT:
Peptide ligands which bind to von Willebrand Factor (vWF) are disclosed. These peptides are selected from the group consisting of RLHSFY, RLKSFY, RLNSFY, RLQSFY, RFRSFY, RIRSFY, RVRSFY, RYRSFY, RLRSFY, HLRSFY, and KLRSFY. The preferred peptide ligand has the sequence RVRSFY. A method of using the disclosed peptides to purify vWF comprises binding the peptides to a support, then passing a solution containing vWF over the supports under condition such that the vWF will selectively bind to the peptides, and then eluting the vWF.

REFERENCES:
patent: 5110907 (1992-05-01), Kosow et al.
patent: 5200510 (1993-04-01), Kumar et al.

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