Peptide ligands for affinity purification of human Factor VIII

Details Peptide ligands for affinity purification of human Factor VIII Peptide ligands for affinity purification of human Factor VIII

1998-09-03

1999-11-30

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530383, 530329, A61K 3800, A61K 3804

Patent

active

059943106

ABSTRACT:
Peptides which bind Factor VIII are disclosed. The peptides have available Factor VIII binding domains having a Trp-His-Tyr-Tyr-His-Gly, His-Ile-Gln-His-Tyr-His, or His-Gln-Tyr-Gly-Tyr-His sequence. Peptides having at least one of these Factor VIII binding domains are immobilized upon a chromatographic substrate in a preferred embodiment of the invention. This preferred embodiment is useful in a chromatography process to purify human Factor VIII.

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