Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence
Patent
1998-01-23
1998-07-21
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
6 to 7 amino acid residues in defined sequence
530382, A61K 3808, C07K 706
Patent
active
057836639
ABSTRACT:
Peptides which bind to fibrinogen are disclosed. These peptides have available fibrinogen binding domains having a Trp-Gln-Glu-His-Tyr-Asn, Trp-Gln-Glu-Thr-TyrGln,or Tyr-Glu-Asn-Tyr-Gly-Tyr sequence. Peptides containing at least one of these fibrinogen binding domains are immobilized upon a chromatographic substrate in a preferred embodiment of the invention. This preferred embodiment is useful in an affinity chromatography process to purify fibrinogen.
REFERENCES:
Baumbach et al. Protein purification using affinity ligands from peptide libraries. BioPharm. 24-35, May 1992.
Buettner et al. Chemically derived peptide libraries: A new resin and methodology for lead identification. Int. J. Peptide Protein Res. 47:70-83, 1996.
Smith et al. A ribonuclease S-peptide antagonist discovered with a bacteriophage display library. Gene 128:37-42, 1993.
Brennan, M. Fibrin glue. Blood Reviews 5:240-244, 1991.
Buettner Joseph A.
Carbonell Ruben C.
Mondorf Kristine
Bayer Corporation
Beck Michael J.
Giblin James A.
Tsang Cecilia J.
Wang Cecilia F.
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