Peptide isolated from micrococcus varians and use thereof

Details Peptide isolated from micrococcus varians and use thereof Peptide isolated from micrococcus varians and use thereof

1997-05-22

1998-05-26

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530300, 530825, C07K 14305

Patent

active

057566658

ABSTRACT:
An isolated peptide which in a microorganism, and particularly in Micrococcus varians, is a signal peptide which initiates expression of a bactericide composition.

REFERENCES:
Cundliffe, et al., "Inhibition of Ribosomal A Site Functions by Sporangiomycin and Micrococcin", Antimicrobial Agents and Chemotherapy, Jul. 1975, pp. 1-4, vol. 8, No. 1.
Piard et al, "Structure, Organization, and Expression of the lct gene for Laciticin 481, a Novel Lantibiotic Produced by Lactococcus lactis, "Journal of Biology Chemistry, vol. 286, pp. 16361-16368 (1993).
Piard, et al, "Purification and Partial Characterization of Lacticin 481, a Lanthionine-Containing Bacteriocin Produced by Lactococcus lactis, subsp, lactis CNRZ 481" Applied and Environmental Microbiology, vol. 58, pp. 279-284 (1992).
Larsen, et al, "Antimicrobial activity of lactic acid bacteria isolated from sour doughs: purification and characterization of bavaricin A, a bacteriocin produced by Lactobacillus bavaricus MI401," Journal of Applied Bacteriology, 1993, 75, 113-122.
Cantoni, et al, "Batteriocine Da Micrococcaceae" Industrie Alimentari 31 (1992), pp. 660-665 and translation thereof commissioned by the USPTO, Bacteriocins From Microccaceae.
Tagg, et al. "Bacteriocins of Gram-Positive Bacteria", 1976, Bacteriol Rev vol. 40, 1976, pp. 722-756;.
Heatley et al, "The Assay of Micrococcin an almost Insoluble Antibiotic", J. Gen. Microbiol. 6, 30-40, 1952.
Heatley et al., "The Preparation and Some Properties of Purified Micrococcin", Biochem. J. 50:247-253, 1951.
Su, "Antibiotic-Producing Organisms in Faeces and Sewage", Br. J. Exp. Pathol. 29:466-473, 1948.
Su, "Micrococcin, An Antibacterial Substance Formed by a Strain of Micrococcus", Br. J. Exp. Pathol. 29:473-481, 1948.
MEDLINE database, abstract, Accession No. 80079859, abstract of Egorov, et al., "Procedure from isolating nisin from Streptococcus lactis", Prikladnaia Biokhimiia I Mikrobiologiia 15:712-714.

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