Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1988-12-20
1990-09-18
Schain, Howard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 18, 514 16, 530329, 530330, 530350, C07K 508, C07K 706, C07K 510
Patent
active
049579029
ABSTRACT:
The present invention involves the inhibition of wound contraction by polypeptides having an amino acid sequence which is similar or identical to certain amino acid sequences of type (I) collagen. A variety of peptides are disclosed which are clinically useful as inhibitors of wound contraction.
REFERENCES:
patent: 4578079 (1986-03-01), Rouslahti et al.
Yamada et al. (1984) Dualistic Nature of Adhesive Protein Function: Fibronectin and its Biologically Active Peptide Fragments can Autoinhibit Fibronectin Function, The Journal of Cell Biology, vol. 99, Jul. 1984, 29-36.
Pierschbacher et al., "Cell Attachment Activity of Fibronectin can be Duplicated by Small Synthetic Fragments of the Molecule" Nature vol. 309, May 3, 1984, 30-33.
Zitelli, "Seconary Intention Healing: an Alternative to Surgical Repair", Clinics in Dermatology vol. 2, 1984, 92-106.
Telios Pharmaceuticals, Inc. sales brochure.
Peacock, Third Edition, "Wound Repair" Contraction 38-55.
Bell et al., "Production of a Tissue-Like Structure by Contraction of Collagen Lattices by Human Fibroblasts of Different Proliferative Potential in vitro", Proc. Natl. Acad. Sci. U.S.A., vol. 76, No. 3, pp. 1274-1278, Mar. 1979, Cell Biology.
Bellows et al., "Fibroblasts Contracting Three-Dimensional Collagen Gels Exhibit Ultrastructure Consistent with Either Contraction or Protein Secretation" Journal of Ultrastructure Research 78, 178-192 (1982).
Ehrlich et al., "Fibroblast Contraction of Collagen Lattices in vitro: Inhibition by Chronic Inflammatory Cell Mediators" Journal of Cellular Physiology 116:345-351 (1983).
Bellows et al., "Association Between Tension and Orientation of Periodontal Ligament Fibroblasts and Exogenous Collagen Fibres in Collagen Gels in vitro" J. Cell Sci. 58, 125-138 (1982).
Stopak et al., "Connective Tissue Morphogenesis by Fibroblast Traction" Developmental Biology 90, 383-398 (1982).
Grinnell et al., "Reorganization of Hydrated Collagen Lattices by Human Skin Fibroblasts" J. Cell Sci. 66, 51-63 (1984).
Guidry et al., "Studies on the Mechanism of Hydrated Collagen Gel Reorganization by Human Skin Fibroblasts" J. Cell Sci. 79, 67-81 (1985).
Guidry et al., "Heparin Modulates the Organization of Hydrated Collagen Gels and Inhibits Gel Contraction by Fibroblasts" The Journal of Cell Biology, vol. 104, Apr. 1987, 1097-1103.
Dedhar et al., "A Cell Surface Receptor Complex for Collagen Type I Recognizes the Arg-Gly-Asp Sequence" The Journal of Cell Biology, vol. 104, Mar. 1987, 585-593.
Steinberg et al., "Establishment and Transformation Diminish the Ability of Fibroblasts to Contract a Native Collagen Gel" The Journal of Cell Biology, vol. 87, Oct. 1980, 304-308.
Donaldson et al., "Newt Epidermal Cell Migration Over Collagen and Fibronectin Involves Different Mechanisms" Journal of Cell Science 90, 325-333 (1988).
Bernard et al., "Structure of a cDNA for the Pro 2 Chaim of Human Type I Procollagen, Comparison with Chick cDNA for Pro 2(I) Identifies Structurally Conserved Features of the Protein and the Gene" Biochemistry 1983, 22, 1139-1145.
Grinnell, "Fibronectin Adsorption on Material Surfaces.sup.a " Annals New York Academy of Sciences, pp. 281-290.
Horwitz et al., "The Cell Substrate Attachment (CSAT) Antigen has Properties of a Receptor for Laminin and Fibronectin" The Journal of Cell Biology, vol. 101, Dec. 1985, 2134-2144.
Hynes, "Integrins: a Family of Cell Surface Receptors" Cell, vol. 48, 549-554, Feb. 27, 1987.
Izzard et al., "Molecular Biology of Cell Motility in vitro" Expl. Biol. Med., vol. 10, pp. 1-22 (Karger, Basel 1985).
Lark, et al., "Close and Focal Contact Adhesions of Fibroblasts to a Fibronectin-Containing Matrix" Federation Proceedings vol. 44, No. 2, Feb. 1985, 394-403.
McKeown-Longo et al., "Interaction of the 70,000-mol-wt Amino-Terminal Fragment of Fibronectin with the Matrix-Assembly Receptor of Fibroblasts" The Journal of Cell Biology, vol. 100, Feb. 1985, 364-374.
Spiegel et al., "Fibrillar Organization of Fibronectin is Expressed Coordinately with Cell Surface Gangliosides in a Bariant Murine Fibroblast" The Journal of Cell Biology, vol. 102, May 1986, 1898-1906.
Grinnell et al., "Cell Adhesion and Phagocytosis Promoted by Monoclonal Antibodies not Directed Against Fibronectin Receptors" Journal of Cell Science 90, 201-214 (1988).
Board of Regents , The University of Texas System
Koh Choon P.
Schain Howard
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