Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Patent
1994-02-08
1997-04-29
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
530326, 530327, 530328, 530329, 530330, C07K 700, C07K 706, C07K 708, C07K 1400
Patent
active
056250312
ABSTRACT:
Novel peptide and peptide mimetic ligands which act as inhibitors of p34.sup.cdc2 kinase, p33.sup.cdk2 kinase and human papillomavirus transforming protein E7 (HPV E7) are disclosed. The inhibitors are derived from the binding domains of a retinoblastoma tumor suppressor protein (Rb), p107 and a cyclin.
REFERENCES:
Bignon et al., Genes & Development 7:1654-1662 (1993).
Freidman, Cancer 70:1810-1817 (1992).
Parker et al, Proc. Natl. Acad. Sci. USA 89:2917-2921 (1992).
Bandara et al., Cyclin A and the retinoblastoma gene product complex with a common transcription factor, (1991) Nature 352:249-252.
Chelappan et al., The E2F transcription factor is a cellular target for the RB protein, (1991) Cell 65:1053-1061.
Cross et al., Simple and Complex cell cycles, (1989) Ann. Rev. Cell Biol. 5:341-395.
Devoto et al., A cyclin A-Protein kinase complex possesses sequence-specific DNA binding activity:p33.sup.cdk2 is a component of the E2F-cyclin A complex, (1992) Cell 68:167-176.
Draetta et al., cdc2 protein kinase is complexed with both cyclin A dn B: Evidence for proteolytic inactivation of MPF, (1989) Cell 56:829-838.
Draetta, Cell cycle control in eukaryotes: Molecular mechanisms of cdc2 activation, (1990) TIBS 15:378-383.
Draetta et al., Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement, (1988), Cell 54:17-26.
Dyson et al., The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product, (1989) Science 243:934-937.
Elledge et al., CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle, (1992) Proc. Natl. Acad. Sci. USA 89:2907-2911.
Ewen et al., Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins, (1992) Science 255:85-87.
Ewen et al., Molecular cloning, chromosomalmapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein, (1991) Cell 66:1155-1164.
Faha et al., Interaction between human cyclin A and adenovirus E1A-associated p107 protein, (1992) Science 255: 87-90.
Furukawa et al., CDC2 gene expression at the G.sub.1 to S transition in human T lymphocytes, (1990) Science 250:805-808.
Gage et al., The E7 proteins of the nonnoncogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties, (1990) J. Virol. 64:723-730.
Giordano et al., A 60 kd CDC2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells, (1989) Cell 981-990.
Gu et al., Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit, (1993) Nature 366:707-710.
Harper et al., The p21 CDK-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases, (1993) Cell 75:805-816.
Horowitz et al., Point mutational inactivation of the retinoblastoma antioncogene, (1989) Science 243:937-940.
Hu et al., The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 latge T antigen are common sites for mutations, (1990) EMBO J. 9:1147-1155.
Hunt, T., Maturation promoting factor, cyclin and the control of M-phase, (1989) Curr. Opinion Cell Biol. 1:268-274.
Kaye et al., A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding, (1990) Proc. Natl. Acad. Sci. USA 87:6922-6926.
Labbe et al., Purification of MPF from starfish: Identification as the H1 histone kinase p34.sup.cdc2 and a possible mechanism for its periodic activation, (1988) Cell 57:253-263.
Lee et al., Cell cycle control genes in fission yeast and mammalian cells, (1988) Trends Genet. 4:287-90.
Lew et al., Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast, (1991) Cell 66:1197-1206.
Motokura et al., A novel cyclin encoded by a bc/1-linked candidate oncogene, (1991) Nature 350:512-515.
Mundryi et al., Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A, (1991) Cell 65:1243-1253.
Murray et al., The role of cyclin synthesis and degradation in the control maturation promoting factor activity, (1989) Nature 339:280-286.
Nurse, Universial controlmechanism regulating onset of M-phase, (1990) Nature 344:503-508.
Pines et al., Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B, (1990) Nature 346:760-763.
Pines et al., Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interactions with p34.sup.cdc2, (1989) Cell 58:833-846.
Rosenblatt et al., Human cyclin-dependent kinase 2 is activated furing the S and G.sub.2 phases of the cell cycle and associated with cyclin A, (1992) Proc. Natl. Acad. Sci. USA 89:2824-2828.
Serrano et al., A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4, (1993) Nature 366:704-707.
Shirodkar et al., The transcription factor E2f interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner, (1992) Cell 68:157-166.
Solomon et al., Cyclin activation of p34.sup.cdc2, (1990) Cell 63:1013-1024.
Tsai et al., Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase, (1991) Nature 353:174-177.
Wang et al., Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma, (1990) Nature 343:555-557.
Whyte et al., Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product, (1988) Nature 334:124-129.
Xiong et al., p21 is a universial inhibitor of cyclin kinases, (1993) Nature 366:701-704.
Xiong et al., Subunit rearrangement of the cyclin-dependent kinases in associated with cellular transformation, (1993) Genes and Development7:1572-1583.
Coleman Kevin G.
Webster Kevin R.
Bristol--Myers Squibb Company
Grimes Eric
Wax Robert A.
LandOfFree
Peptide inhibitors of the p33.sup.cdk2 and p34.sup.cdc2 cell cyc does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Peptide inhibitors of the p33.sup.cdk2 and p34.sup.cdc2 cell cyc, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide inhibitors of the p33.sup.cdk2 and p34.sup.cdc2 cell cyc will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-706771