Peptide inhibitors of selectin binding

Details Peptide inhibitors of selectin binding Peptide inhibitors of selectin binding

1995-06-01

1997-04-08

Horlick, Kenneth R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530328, A61K 3808, C07K 706

Patent

active

056187858

ABSTRACT:
The present invention provides novel peptides constructed to mimic the topology of the surface exposed segements of the 23-30 sequence and Tyr.sup.118 in the lectin domain of P-selectin. The invention also provides pharmaceutical compositions comprising the peptides of the invention, and diagnostic and therapeutic methods utilizing the peptides and pharmaceutical compositions of the invention.

REFERENCES:
patent: 3625214 (1971-12-01), Higuchi
patent: 4906474 (1990-03-01), Langer et al.
patent: 4925673 (1990-05-01), Steiner et al.
patent: 5081034 (1992-01-01), Bevilacqua et al.
patent: 5116964 (1992-05-01), Capon et al.
patent: 5192746 (1993-03-01), Lobl et al.
patent: 5198424 (1993-03-01), McEver
patent: 5227369 (1993-07-01), Rosen et al.
patent: 5378464 (1995-01-01), McEver
patent: 5440015 (1995-08-01), Macher et al.
patent: 5464935 (1995-11-01), Heavner et al.

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