Peptide inhibitors of nuclear protein translocation having nucle

Details Peptide inhibitors of nuclear protein translocation having nucle Peptide inhibitors of nuclear protein translocation having nucle

1997-09-12

1999-03-02

Carlson, Karen Cochrane

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 1400

Patent

active

058772820

ABSTRACT:
Novel polypeptide inhibitors of cytoplasmic protein nuclear translocation are disclosed. The inhibitors are comprised of a signal sequence and at least two nuclear localization sequences. The polypeptides are useful as immunosuppression, antiviral and antitumor agents.

REFERENCES:
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Imamura et al, "Identification of a Heparin-Binding Growth Factor-I Nuclear Translocation Sequence by Deletion Mutation Analysis," Journal of Biological Chemistry 267:(8)5676-5679 (1992).
Kentrup et al., "Dyrk, a Dual Specificity Protein Kinase With Unique Structural Features Whose Activity is Dependent on Tyrosine Residues Between Subdomains VII and VIII," The Journal of Biological Chemistry 271:(7)3488-3498 (1996).
Mukaigawa et al., "Two Signal Mediate Nuclear Localization of Influenza Virus (A/WSN/33) Polymerase Basic Protein 2," Journal Virology 65:(1)253-254 (1991).
Perez et al., "Antennapedia Homeobox as a Signal for the Cellular Internalization and Nuclear Addressing of a Small Exogenous Peptide," Journal of Cell Science 102:717-722 (1992).
Theodore et al., "Intraneuronal Delivery of Protein Kinase C Pseudosubstrate Leads to Growth Cone Collapse," The J. of Neuroscience 15(11):7158-7167 (1995).

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