Peptide inhibitors of fibronectin and related collagen-binding p

Details Peptide inhibitors of fibronectin and related collagen-binding p Peptide inhibitors of fibronectin and related collagen-binding p

1992-11-10

1996-02-13

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 514 16, 514 17, 530328, 530329, 530330, 530327, A61K 3800, C07K 700, C07K 706, C07K 708

Patent

active

054911303

ABSTRACT:
Peptides derived from the second type 1 repeat of human endothelial cell thrombospondin which bind to the gelatin-binding domain of fibronectin have been isolated and synthetically produced. The peptides can be used to bind to fibronectin or other related collagen-binding proteins to inhibit fibronectin-dependent cell adhesion to collagen matrices and to inhibit interactions with collagen of other proteins that share homologies with the gelatin-binding domain of fibronectin.

REFERENCES:
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patent: 5200397 (1993-04-01), Deutch et al.
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Jack Lawlor et al, "The Structure of Human Thrombospondin, an Adhesive Glycoprotein with Multiple Calcium-Homologies with Several Different Proteins", The Rockefeller University Press, The Journal of Cell Biology vol. 103, pp. 1635-1648, Nov. 1986.
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Frank B. Gelder et al, "Fibronectin Gelatin-binding Activity: Effects of Platelet Thrombospondin, Serum, and Plasma", Louisiana State University, Depts. of Surgery and Medicine, pp. 548-557, Jul 8, 1986.
E. Helene Sage et al, "Extracellular Proteins That Modulate Cell-Matrix Interactions", The Journal of Biological Chemistry, vol. 266, No. 23, pp. 14831-14834, Aug. 15, 1991.
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Neng-Hua Guo et al, J. Biol Chem, vol. 267, Sep. 25, 1992.

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