Peptide inhibiting platelet derived growth factor (PDGF-BB)...

Details Peptide inhibiting platelet derived growth factor (PDGF-BB)... Peptide inhibiting platelet derived growth factor (PDGF-BB)...

2006-03-07

2006-03-07

Weber, Jon (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Reexamination Certificate

active

07009036

ABSTRACT:
A novel peptide, derived from the human fibroblast growth factor (bFGF), is identified. The molecule is able to inhibit in vitro the effects of Platelet Derived Growth Factor (PDGF-BB) and basic Fibroblast Growth Factor (bFGF) on primary rat smooth muscle cells (RASMC) and primary bovine endothelial cells (BAEC) The molecule is also able to inhibit in vivo angiogenesis CD1 mice.

REFERENCES:
patent: 5252718 (1993-10-01), Baird et al.
patent: 00/53219 (2000-09-01), None
patent: 00/72004 (2000-11-01), None
Antonio Facchiano et al., “Identification of a Novel Domain of Fibroblast Growth Factor 2 Controlling Its Angiogenic Properties,” The Journal of Biological Chemistry, V. 278, 2003, pp. 8751-8760.

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