Peptide hydroxamic acid derivatives

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.

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530810, 530813, C07C10352

Patent

active

046878416

ABSTRACT:
Novel peptide hydroxamic acid derivatives having useful collagenase inhibitory activity and capable of forming affinity resins for the purification of vertebrate collagenase are defined by the following structural formula:

REFERENCES:
patent: 3931184 (1976-01-01), Lex
patent: 4138394 (1979-02-01), Sakakibara et al.
patent: 4443367 (1984-04-01), Weingarten
patent: 4466919 (1984-08-01), Weingarten
Masui et al. Biochem. Med. 17, 215-221 (1977).
Nishino and Powers, Biochem. 17, 2846 (1978).
Nishino and Powers, Biochem. 18, 4340-4347 (1979).

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