Peptide having osteogenetic activity and osteogenetic...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence

Reexamination Certificate

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Details

C514S012200, C514S013800, C514S015800, C514S018700, C530S326000, C530S328000, C530S330000

Reexamination Certificate

active

07132506

ABSTRACT:
A peptide has at least an amino acid sequence represented by SEQ ID NO:1 and it has an osteogenetic activity.

REFERENCES:
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patent: 6617307 (2003-09-01), Nishimura et al.
patent: 2002/0120103 (2002-08-01), Rosen et al.
John M. Wozney, et al., “Novel Regulators of Bone Formation: Molecular Clones and Activities”, Science vol. 242, pp. 1528-1534, (1990).
Elizabeth A Wang, et al., “Recombinant Human Bone Morphogenetic Protein Induces Bone Formation”, Proc. Natl. Acad. Sci. USA, pp. 2220-2224 (1990).
Molecular Medicine vol. 30, No. 10 (1993).
Sequel to Biochemical Experiments 2, Chemistry about Protein (the second volume) May 20, 1987.
E. Atherton, et al., “Solid Phase Peptide Synthesis”, pp. 149-157, (1989).
Yoshihisa Suzuki, et al., “Evaluation of a Novel Alginate Gel Dressing: Cytotoxicity to Fibroblasts in Vitro and Foreign-Body Reaction in Pig Skin in Vitro”, J. Biomed Mater Res, 39, pp. 317-322, (1998).
Klaus Mosbach, “Immobilized Enzymes and Cells”, Method in Enzymology, vol. 135, pp. 30-65, (1987).
Suzuki, et al., “Alginate Hydrogel Linked with Synthetic Oligopeptide Derived from BMP-2 Allows Ectopic Osteoinduction in Vivo.” Journal of Biomedical Materials Research. United States, Jun. 5, 2000 pp. 405-409.
Database EMBL Online, Oct. 1, 1989.

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