Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence
Reexamination Certificate
2011-06-14
2011-06-14
Garcia, Marcela M Cordero (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
6 to 7 amino acid residues in defined sequence
C514S021300, C514S021400
Reexamination Certificate
active
07960508
ABSTRACT:
A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.
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Akiyama Katsuhiko
Goto Takeshi
Hattori Wataru
Hirashima Masaki
Maeda Hiroaki
Birch & Stewart Kolasch & Birch, LLP
Cordero Garcia Marcela M
Hisamitsu Pharmaceutical Co. Inc.
Juridical Foundation The Chemo-Sero-Therapeutic Research Institu
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