Peptide having antigenic properties similar to "a "determinant o

Details Peptide having antigenic properties similar to "a "determinant o Peptide having antigenic properties similar to "a "determinant o

1995-04-05

1997-09-16

Loring, Susan A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530328, C07K 704, C07K 706, C07K 14005, C07K 1402

Patent

active

056682530

ABSTRACT:
The invention comprises an anti-idiotypic antibody designated 2F10 and permitted variants thereof, which have antigenic properties similar to the group specific "a" determinant of human hepatitis B surface antigen HBsAg and have at least partial but not complete homology with such surface antigen. The invention further comprises a peptide having a chain comprising the amino acid residues Ala Val Tyr Tyr Cys Thr Arg Gly Tyr His Gly Ser Ser Leu Tyr and permited variants thereof, which, like 2F10, have antigenic properties similar to the group specific "a" determinant of human hepatitis B surface antigen HBsAg and have at least partial, but not complete, homology with said surface antigen. The amino acid sequence is found in and forms a part of 2F10. The shorter peptide chain comprising the amino acid residues Gly Tyr His Gly Ser Ser Leu Tyr and permited variants thereof, also have antigenic properties similar to the group specific "a" determinant of human hepatitis B surface antigen HBsAg and have at least partial, but not complete, homology with said surface antigen.

REFERENCES:
patent: 4778761 (1988-10-01), Miyanohara et al.
patent: 4803164 (1989-02-01), Hitzeman et al.
Wands et al., "Identification and Transmission of Hepatitis B virus-related variants", Proc. Natl. Acad. Sci. USA, vol. 83, pp. 6608-6612, Sep. 1986.
"HBsAG Positive Reactivity in Man Not Due to Hepatitis B Virus", The Lancet, The Lancet, Dec. 12, 1987.
Neurath et al., "Toleration of Amino Acid Substitutions within Hepatitis B Virus Envelope Protein Epitopes Established by Peptide Replacement Set Analysis. I. Region S(139-147)" Peptide Research, vol. 3, No. 3 (1990).
Lai et al., "Hepatitis B virus DNA in the Serum of Sardinian Blood Donors Negative for the Hepatitis B Surface Antigen", Blood, Jan. 1989, 73(1) pp. 17-19.
Carman et al., "Vaccine-induced Escape Mutant of Hepatitis B Virus", The Lancet vol. 336, pp. 325-329 (Aug. 1990).
Egea et al., "The Cellular Basis for Lack of Antibody Response to Hepatitis B Vaccine in Humans", Exp. Med., vol. 173, pp. 531-538 (Mar. 1991).
Cupps et al., "In Vitro Immune Responses to Hepatitis B Surface Antigens S and preS2 during Acute Infection by Hepatitis B Virus in Humans", The Journal of Infectious Diseases, 161, pp. 412-419 (1990).
Cupps et al., "In Vitro Immune Responses to Hepatitis B Surface Antigen (Pre-S2 and S) Following Remote Infection by Hepatitis B Virus in Humans", Journal of Clinical Immunology, vol. 9, No. 3, (1989).
Jin et al., "Human T Cell Response to the Surface Antigen of Hepatitis B Virus (HBsAg)", Journal of Experimental Medicine, vol. 168, pp. 293-306 (1988).
Jin et al., "An Oligoclonual Human T-Cell Line Specific for HBsAg is Restricted to MHC Class I Antigens and Responds to Soluble Antigen and to Endogenous HBsAg" Viral Hepatitis and Liver Disease, pp. 678-683 (1988).
Chang et al., "In Vitro Response to HBsAg of Peripheral Blood Lymphocytes from Recipients of Hepatitis B Vaccine", Hepatology, vol. 4, No. 5, pp. 824-829 (1984).
Celis et al., "Recognition of Hepatitis B Surface Antigen by Human T Lymphocytes" The Journal of Immunology, vol. 140, pp. 1808-1815, No. 6 (1988).
Celis et al., "Hepatitis B Virus-Reactive Human T Lymphocyte Clones: Antigen Specificity and Helper Function for Antibody Synthesis", The Journal of Immunol. vol. 132, No. 3, (1984).
Pride et al., "Stimulation of Murine and Human HBsAG Specific B and T Cells by an `internal image` anti-Id", pp. 263-270 (1990).
Brown et al., "Affinity of Antibody Responses in Man to Hepatitis B Vaccine determined with Synthetic Peptides", Lancet, Jul. 1984, 2(8396) pp. 184-187.
Okamoto et al., "The Loss of Subtypic Determinants in Alleles, d/y or w/r, on Hepatitis B Surface Antigen", Molecular Immunol. vol. 26, No. 2, pp. 197-205, (1989).
Lai et al., "Hepatitis B Virus DNA in the Serum of Sardinian Blood Donors Negative for the Hepatitis B Surface Antigen", Blood, vol. 73, No. 1 pp. 17-19 (1989).
Brown et al., "Determination of the Affinity of Antibodies to Hepatitis B Surface Antigen in Human Sera", Journal of Immunol. Methods, 72, pp. 41-48 (1984).
Delpeyroux et al., "Insertions in the Hepatitis B Surface Antigen", J. Mol. Bio 195, pp. 343-350 (1987).
Delpeyroux et al., "Presentation and Immunogenicity of the Hepatitis B Surface Antigen and a Poliovirus Neutralization Antigen on Mixed Empty Envelope Particles" Journal of Virology, pp. 1836-1839, (1988).

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