Peptide having an affinity for gp120

Details Peptide having an affinity for gp120 Peptide having an affinity for gp120

2007-11-06

2007-11-06

Chen, Stacy B. (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S188100, C435S005000

Reexamination Certificate

active

10909310

ABSTRACT:
The peptide in this invention is a peptide having affinity to gp120 represented by Formula (1): H-A1-A2-A3-A4-A5-R(SEQ ID No. 1)(in the formula,H means hydrogen,A1 is aspartic acid, lysine, valine, glutamic acid, glycine, asparagine, or tyrosine residue,A2 is valine, aspartic acid, tryptophan, lysine, phenylalanine, isoleucine,leucine, or tyrosine residue,A3 is lysine, valine, aspartic acid, arginine, alanine, or tryptophan residue,A4 is alanine, tryptophan, or glycine residue,A5 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, methionine, asparagine, glutamine, histidine, lysine, arginine, phenylalanine, tryptophan, proline, or tyrosine residue,R is OH derived from carboxyl group or NH2derived from acid amide group).The above peptide has an affinity to gp120 of the HIV envelope protein and is superior in stability.

REFERENCES:
patent: 6503729 (2003-01-01), Bult et al.
patent: 10-182695 (1998-07-01), None
patent: 10-182696 (1998-07-01), None

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