Peptide fructose and protein conjugate with the same

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...

Reexamination Certificate

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C530S387900, C530S809000, C530S406000, C435S070210, C435S070200, C436S548000, C436S823000

Reexamination Certificate

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07109309

ABSTRACT:
It is intended to provide an antibody specific to HbA1c, antibody-producing cells capable of supplying the antibody in a stable state in the future, and a method of constructing the antibody-producing cells without any probability factors, and a method which comprises fusing mouse spleen cells, which have been sensitized with an immunogen composed of a compound containing the following structural formula (I) and a binding protein, with a myeloma-origin cell line, obtaining monoclonal antibody-producing cells by cloning, and then purifying and acquiring the monoclonal antibody produced by these cells into the culture supernatant

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T. Azuma, et al., “Maturation of the Immune Response to (4-Hydroxy-3-Nitrophenyl)-Acetyl (NP) Haptens In C57BL/8 Mice”, Molecular Immunology. 24(3) 287-296 (1987).

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