Peptide fragments of tissue plasminogen activator

Details Peptide fragments of tissue plasminogen activator Peptide fragments of tissue plasminogen activator

1989-11-06

1991-08-13

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

514 12, C07K 710, A61K 3702, A61K 3718

Patent

active

050397915

ABSTRACT:
Novel peptide fragments of tissue plasminogen activator are described which have activity for inhibiting (a) the binding of tPA to human endothelial cells, and (b) the inactivation of tPA by plasminogen activator inhibitor-1 (PAI-1). Six peptides or peptide amides with these activities have the sequences, numbered according to the native protein:

REFERENCES:
Ny et al., Proc. Natl. Acad. Sci. U.S.A. 81, 5355-5359 (1984).
Hajjar et al., J. Clin. Invest. 80, 1712-1719 (1987).
Barnathan et al., J. Biol. Chem. 263, 7792-7797 (1988).
Beebe, Thromb. Res. 46, 241-254 (1987).
Sakata et al., J. Biol. Chem. 263, 1960-1969 (1988).
Chmielewska et al., Biochem. J. 251, 327-332 (1988).
Van Zonnenveld et al., J. Cellular Biochem. 32, 169-178 (1986).

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