Peptide fragments of murine epidermal growth factor as...

Details Peptide fragments of murine epidermal growth factor as... Peptide fragments of murine epidermal growth factor as...

2006-02-07

2006-02-07

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C530S328000, C530S334000, C530S335000, C530S336000, C530S344000, C530S399000, C435S007100, C424S009100

Reexamination Certificate

active

06995136

ABSTRACT:
A peptide factor, its analogs and methods of using such peptide factor derived from murine epidermal growth factor peptide is disclosed wherein the peptide factor is modified to protect it from proteolytic degradation and the peptide binds to laminin receptors.

REFERENCES:
patent: 4686283 (1987-08-01), Nestor, Jr. et al.
Nelson et al., J. Biol. Chem. 271, 26179-26186 (1996).
Baileie, J. R. et al: “Synthesis and receptor-binding activity of peptide fragments of epidermal growth factor” Biochem. Soc. Trans. (1989), 17(2), 409-10, 1989, XPOO2116635 p. 409, right-hand column; table 1.
McFerran, Neil V. et al: “A peptide molecular dynamics study correlates structure with function”Biochem. Soc. Trans. (1996), 24(1), 127s, 1996, XPOO2116636 p. 127s, left-hand column, paragraph 4.
Nelson, John et al: “Murine epidermal growth factor (EGF) fragment (33-42) inhibits both EGF-and laminin-dependent endothelial cell motility and angiogenesis” Cancer Res. (1995), 55(17), 3772-6, 1995, XP002116637 p. 228.
Nelson, John et al: Murine epidermal growth factor peptide (33-42) binds to a YIGSR-specific laminin receptor on both tumor and endothelial cells: J. Biol. Chem. (1996), 271(42), 26179-26186, 1996, XP002116638 p. 26183, left-hand colun, paragraph 3 p. 26186, left-hand column, last paragraph.

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