Peptide fragments of HIV

Details Peptide fragments of HIV Peptide fragments of HIV

1992-12-31

1995-10-17

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530327, 530350, C07K 700, C07K 706, C07K 708, C07K 1415

Patent

active

054592380

ABSTRACT:
Peptides are described which have the amino acid sequence of a fragment of HIV (human immunodeficiency virus) which interacts specifically with a particular human leucocyte antigen (HLA) class I molecule, to stimulate cytotoxic T lymphocyte immunity. Such fragments can be used in a potential vaccine against AIDS (acquired immune deficiency syndrome), and for diagnostic and therapeutic purposes.

REFERENCES:
patent: 4772547 (1988-09-01), Heimar et al.
patent: 4808536 (1989-02-01), Chang et al.
Butini, et al, 1994, "Comparative analysis of HIV-Specific . . . " J. Cell. Biochem. Supplement 18B, p. 147, abstract J 306.
McMichael, et al., 1986, "HLA B37 Determines an . . . " J. Exp. Med. 164:1397-1406.
Gotch, et al., 1987, "Cytotoxic T lymphocytes recognize a . . . " Nature 326:881-882.
Walker, et al, 1987, "HIV-Specific Cytotoxic T lympocytes . . . " Nature 328: 345-348.
Wahren, et al., 1987, "Characteristics of the specific Cell-mediated . . . " J. Virol. 61(6):2017-2023.

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