Peptide fragments containing HP and LP cross-links

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides with at least one nonpeptide bond other than a...

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530325, 530326, 530387, 530834, 435 7, C07K 702

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active

049736663

ABSTRACT:
A method for assaying bone resorption rates by quantitating the concentration of peptide fragments derived from bone collagen, found in a body fluid. The method includes immunometric assay, fluorometric assay and electrochemical titration. The structure of specific peptide fragments having 3-hydroxypyridinium cross-links found in urine of Paget's disease patients and procedures for making monoclonal antibodies is also described.

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