Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2011-04-19
2011-04-19
Kemmerer, Elizabeth C. (Department: 1646)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S016400, C514S021300, C514S021500, C530S300000, C530S324000, C530S327000, C530S387900, C536S023100, C536S023500
Reexamination Certificate
active
07928057
ABSTRACT:
The present invention relates to a method for diagnosing susceptibility for a myocardial and/or immunological disorder, a kit and a therapeutic agent comprising a peptide of SEQ ID NO: 1 or 2 and uses thereof.
REFERENCES:
patent: 2003/0045679 (2003-03-01), Crawford
patent: 2003/0060399 (2003-03-01), Brophy et al.
patent: WO 00/28011 (2000-05-01), None
patent: WO 02/50097 (2002-06-01), None
Phillips, 2001, Journal of Pharmacy and Pharmacology 53:1169-1174.
Verma et al., 1997, Nature 389:239-242.
Anonymous, Internet Article, Calcineurin A Antibodies, Jan. 2005.
Aramburu, J., et al., “Affinity-Driven Peptide Selection of an NFAT Inhibitor More Selective than Cyclosporin A,” Science, vol. 285, pp. 2129-2133, Sep. 1999.
Burkard, N., et al., “Targeted Proteolysis Sustains Calcineurin Activation,” Circulation, vol. 111, pp. 1045-1053, 2005.
Cyert, M.S., “Regulation of Nuclear Localization during Signaling,” J. of Biology Chemistry, vol. 276, No. 24, pp. 20805-20808, Jun. 2001.
Dolmetsch, R., et al., “Differential Activation of Transcription Factors Induced by CA2+Response Amplitude and Duration,” Nature. vol. 386, pp. 855-858, Apr. 1997.
Fornerod, M., et al., “CRM1 is an Export Receptor for Leucine-Rich Nuclear Export Signals,” Cell, vol. 90, pp. 1051-1060, Sep. 1997.
Frey, N., et al., Calsarcins, a Novel Family of Sarcomeric Calcineurin-Binding Proteins, Proc. Natl. Acad. Sci., pp. 14632-14637, Dec. 2000.
Gasiorowski, J., et al., “Mechanisms of Nuclear Transport and Interventions,” Advanced Drug Delivery Reviews, vol. 55, pp. 703-716, 2003.
Hallhuber, M., et al., Inhibition of Nuclear Import of Calcineurin Prevents Myocardial Hypertrophy, Circulation Research, vol. 99, pp. 626-635, 2006.
Hallhuber, M., et al., “New Approach to Prevent Myocardial Hypertrophy,” Future Cardiology, vol. 3, pp. 91-98, 2007.
Hogan, P.G., et al., “Modification by Nuclear Export?” Nature, vol. 398, pp. 200-201, 1999.
Jans, D., et al. “Nuclear Targeting Signal Recognition: A Key Control Point in Nuclear Transport?” BioEssays, vol. 22, pp. 532-544, 2000.
Kutay, U., et al., “Export of Importin α from the Nucleus is Mediated by a Specific Nuclear Transport Factor,” Cells, vol. 90, pp. 1061-1071, Sep. 1997.
McKinsey, T., et al., Signal-Dependent Nuclear Export of a Histone Deacetylase Regulates Muscle Differentiation, Nature, vol. 408, pp. 106-111, Nov. 2000.
Pemberton, L., et al., “Mechanisms of Receptor-Mediated Nuclear Import and Nuclear Export,” Traffic, vol. 6, pp. 187-198, 2005.
Ritter, O., et al., “Calcineurin in Human Heart Hypertrophy,” Circulation, vol. 105, pp. 2265-2269, 2002.
Ritter, O., et al. “AT2-Receptor Activation Regulates Myocardial eNOS Expression Via the Calcineurin-NF-AT Pathway,” FASEB Journal, vol. 17, pp. 283-285, 2003.
Shibasaki, F., et al., “Role of Kinases and the Phosphatase Calcineurin in the Nuclear Shutting of Transcription Factor NF-AT4,” Nature, vol. 382, pp. 370-373, Jul. 1996.
Timmerman, L., et al., “Rapid Shutting of NF-AT in Discrimination of CA2+Signals and Immunosuppression,” Nature, vol. 383, pp. 837-840, 1996.
Wilkins, B., et al., “Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy,” Circulation Research vol. 94, pp. 110-118, 2004.
Wu, H., et al., “Critical Role of Calpain-Mediated Cleavage of Calcineurin in Excitotoxic Neurodegeneration,” J. of Biology Chemistry, vol. 279, pp. 4929-4940, 2004.
Zhu, J., et al., “NF-AT Activation Requires Suppression of Crm1-Dependent Export by Calcineurin,” Nature, vol. 398, pp. 256-260, 1999.
Zou, Y., et al., “Isopreternol Activates Extracellular Signal-Regulated Protein Kinases in Cardiomyocytes through Calcineurin,” Circulation, vol. 104, pp. 102-108, 2001.
Jagtiani Ajay A.
Julius-Maximilians-Universitaet Wuerzburg
Kemmerer Elizabeth C.
Vedder Price P.C.
LandOfFree
Peptide for inhibition of calcineurin, nucleic acid,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Peptide for inhibition of calcineurin, nucleic acid,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide for inhibition of calcineurin, nucleic acid,... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2660936