Peptide for diagnosing and immunizing against T. cruzi infection

Details Peptide for diagnosing and immunizing against T. cruzi infection Peptide for diagnosing and immunizing against T. cruzi infection

1992-02-14

1994-04-19

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

530300, 530324, 530325, 435 691, A61K 39005, A61K 3702, C07K 500, C07K 1500

Patent

active

053043715

ABSTRACT:
There is disclosed an antigenic peptide that comprises at least 15 amino acids having the sequence Ala Glu Pro Lys X Ala Glu Pro Lys X Ala Glu Pro Lys X, wherein X is Pro or Ser. This peptide is useful in an ELISA assay to detect antibodies specific to T. cruzi infection and Chagas disease. This peptide is further useful in a vaccine composition for immunizing an individual to prevent Chagas disease upon exposure to T. cruzi.

REFERENCES:
Martinez et al. Inf & Imm 59:4275-4277 1991.
Mitchell Parasitology, 1989:S19-S28 Vaccines & Vaccination Strategies.
Peterson Nature 332:566-568 1986.
Ibanez et al., "Antigenic determinants of Trypanosoma cruzi defined by cloning of parasite DNA", Mol. Biochem. Parasit. 25:175-184 (1987).
Ibanez et al., "Multiple Trypanosoma cruzi antigens containing tandemly repeated amino acid sequence motifs", Mol. Biochem. Parasit. 30:27-34 (1988).
Affranchino et al., "Identification of a Trypanosoma cruzi antigen that is shed during the acute phase of Chagas' disease", Mol. Biochem. Parasit. 34:221-228 (1989).
Frasch and Reyes, "Diagnosis of Chagas Disease Using Recombinant DNA Technology", Parasit. Today 6:137-139 (1990).
Hoft et al., "Trypanosoma cruzi Expresses Diverse Repetitive Protein Antigens", Inf. and Immun. 57:1959-1967 (1989).
Vergara et al., "Assay for Detection of Trypanosoma cruzi Antibodies in Human Sera Based on Reaction with Synthetic Peptides", J. Clin. Microbiol. 29:2034-2037 (1991).
Burns et al., "Identification and synthesis of a major conserved antigenic epitope of pi Trypanosoma cruzi", Proc. Natl. Acad. Sci. USA 89:1239-1243 (1992).
Peterson et al., "Cloning of a major surface-antigen gene of Trypanosoma cruzi and identification of a nonapeptide repeat", Nature 322:566-567 (1986).
Reed, Annual Meeting of the American Society of Tropical Medicine and Hygiene, round table presentation; Nov. 1990.

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