Peptide for detecting antibodies to a 260 kD T. cruzi antigen

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 792, 435 794, 435975, 436518, 436532, G01N 33569

Patent

active

054139120

ABSTRACT:
There is disclosed an antigenic peptide that comprises at least 15 amino acids having the sequence Ala Glu Pro Lys X Ala Glu Pro Lys X Ala Glu Pro Lys X, wherein X is Pro or Ser. This peptide is useful in an ELISA assay to detect antibodies specific to T. cruzi infection and Chagas disease. This peptide is further useful in a vaccine composition for immunizing an individual to prevent Chagas disease upon exposure to T. cruzi.

REFERENCES:
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Frasch and Reyes, Parasit. Today 6:137-139; 1990.
Hoft et al., Inf. and Immun. 57:1959-1967; 1989.
Vergara et al., J. Clin. Microbiol. 29:2034-2037; 1991.
Peterson et al., Nature 322:566-567; 1986.
Reed, Annual Meeting of the American Society of Tropical Medicine and Hygiene, round table presentation; Nov. 1990.
Martinez et al., Infection and Immunity, 59:4275-4277; 1991.
Mitchell, "Vaccines and Vaccination Strategy," in Parasitology; 1989; pp. 519-528.
Burns et al, "Identification and Synthesis of a Major Conserved Antigenic Epitope of Trypanosoma cruzi", Proc. Natl. Acad. Sci. USA, 8(4):1239-1243 (Feb. 15, 1992).

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