Peptide for blocking autoantibody-evoked activation of glutamate

Details Peptide for blocking autoantibody-evoked activation of glutamate Peptide for blocking autoantibody-evoked activation of glutamate

1994-11-28

1998-03-24

Allen, Marianne P.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

24 amino acid residues in defined sequence

C07L 14435, A61K 3816

Patent

active

057314101

ABSTRACT:
A peptide containing 24 amino acid residues that binds to anti-neuronal-glutamate-receptor autoantibodies associated with Rasmussen's encephalitis and that blocks activation of the GluR3 subunit is described. Methods of making the peptide and treating Rasmussen's encephalitis are also disclosed. Autoantibodies to other glutamate receptor subunits are associated with paraneoplastic neurodegenerative disease, amyotrophic lateral sclerosis, and neurodegenerative disease of unknown diagnosis. Methods of screening patients and of monitoring patients being treated for these disorders and syndromes are further described.

REFERENCES:
Wenthold et al, Journal of Biological Chemistry, 267 (1) 501-507, Jan. 5. 1992.
Boulter et al, Science, vol. 249: 1033-1037, 31 Aug. 1990.

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